Complementarity Determining Regions
"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
| Descriptor ID |
D022801
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| MeSH Number(s) |
D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
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| Concept/Terms |
Complementarity Determining Regions- Complementarity Determining Regions
- Region, Complementarity Determining
- Regions, Complementarity Determining
- Hypervariable Regions, Immunoglobulin
- Hypervariable Region, Immunoglobulin
- Immunoglobulin Hypervariable Region
- Immunoglobulin Hypervariable Regions
- Region, Immunoglobulin Hypervariable
- Regions, Immunoglobulin Hypervariable
- Complementarity Determining Region
- Complementarity-Determining Region
- Complementarity-Determining Regions
- Regions, Complementarity-Determining
Complementarity Determining Region 3- Complementarity Determining Region 3
- Complementarity-Determining Region 3
- Complementarity-Determining Region 3s
- Third Complementarity-Determining Region
- Complementarity-Determining Region, Third
- Complementarity-Determining Regions, Third
- Third Complementarity Determining Region
- Third Complementarity-Determining Regions
- Complementarity Determining Region III
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Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".
Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".
This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2004 | 2 | 1 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.
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Clemente MJ, Przychodzen B, Jerez A, Dienes BE, Afable MG, Husseinzadeh H, Rajala HL, Wlodarski MW, Mustjoki S, Maciejewski JP. Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. Blood. 2013 Dec 12; 122(25):4077-85.
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Lauer TM, Agrawal NJ, Chennamsetty N, Egodage K, Helk B, Trout BL. Developability index: a rapid in silico tool for the screening of antibody aggregation propensity. J Pharm Sci. 2012 Jan; 101(1):102-15.
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Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biol Ther. 2009 Nov; 8(22):2147-52.
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Friedman TM, Goldgirsh K, Berger SA, Zilberberg J, Filicko-O'Hara J, Flomenberg N, Donato M, Rowley SD, Korngold R. Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vbeta use: a new paradigm for designer allogeneic blood and marrow transplantation. Blood. 2008 Oct 15; 112(8):3517-25.
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Salajegheh M, Rakocevic G, Raju R, Shatunov A, Goldfarb LG, Dalakas MC. T cell receptor profiling in muscle and blood lymphocytes in sporadic inclusion body myositis. Neurology. 2007 Oct 23; 69(17):1672-9.
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Link JM, Larson JE, Schroeder HW. Despite extensive similarity in germline DH and JH sequence, the adult Rhesus macaque CDR-H3 repertoire differs from human. Mol Immunol. 2005 May; 42(8):943-55.
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Rosson D, Keshgegian AA. Frequent mutations in the mitochondrial control region DNA in breast tissue. Cancer Lett. 2004 Nov 08; 215(1):89-94.
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Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. J Mol Biol. 2004 Sep 17; 342(3):901-12.
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Horie T, Shen Y, Kajino K, Gaubin M, Bonomi G, Mani JC, Berezov A, Piatier-Tonneau D, Guardiola J, Hillard B, Rostami A, Greene M, Murali R. Study of disabling T-cell activation and inhibiting T-cell-mediated immunopathology reveals a possible inverse agonist activity of CD4 peptidomimetics. Exp Mol Pathol. 2002 Oct; 73(2):93-103.
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Manne J, Mastrangelo MJ, Sato T, Berd D. TCR rearrangement in lymphocytes infiltrating melanoma metastases after administration of autologous dinitrophenyl-modified vaccine. J Immunol. 2002 Sep 15; 169(6):3407-12.