Below are the most recent publications written about "DNA Topoisomerase IV" by people in Profiles.
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Werner MM, Patel BA, Talele TT, Ashby CR, Li Z, Zauhar RJ. Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines. Bioorg Med Chem. 2015 Sep 15; 23(18):6125-37.
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Biedenbach DJ, Huband MD, Hackel M, de Jonge BL, Sahm DF, Bradford PA. In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens. Antimicrob Agents Chemother. 2015 Oct; 59(10):6053-63.
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Kim HY, Wiles JA, Wang Q, Pais GC, Lucien E, Hashimoto A, Nelson DM, Thanassi JA, Podos SD, Deshpande M, Pucci MJ, Bradbury BJ. Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). J Med Chem. 2011 May 12; 54(9):3268-82.
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Wiles JA, Phadke AS, Bradbury BJ, Pucci MJ, Thanassi JA, Deshpande M. Selenophene-containing inhibitors of type IIA bacterial topoisomerases. J Med Chem. 2011 May 12; 54(9):3418-25.
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Pucci MJ, Podos SD, Thanassi JA, Leggio MJ, Bradbury BJ, Deshpande M. In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens. Antimicrob Agents Chemother. 2011 Jun; 55(6):2860-71.
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Davies TA, Yee YC, Bush K, Sahm D, Evangelista A, Goldschmidt R. Effects of the 7-valent pneumococcal conjugate vaccine on U.S. levofloxacin-resistant Streptococcus pneumoniae. Microb Drug Resist. 2008 Sep; 14(3):187-96.
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Vitali R, Cesi V, Tanno B, Ferrari-Amorotti G, Dominici C, Calabretta B, RaschellĂ G. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide. Biochem Biophys Res Commun. 2008 Apr 4; 368(2):350-6.
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Cheng J, Thanassi JA, Thoma CL, Bradbury BJ, Deshpande M, Pucci MJ. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Antimicrob Agents Chemother. 2007 Jul; 51(7):2445-53.
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Davies TA, Yee YC, Goldschmidt R, Bush K, Sahm DF, Evangelista A. Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999-2003). J Antimicrob Chemother. 2006 Mar; 57(3):437-42.
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Wiles JA, Hashimoto A, Thanassi JA, Cheng J, Incarvito CD, Deshpande M, Pucci MJ, Bradbury BJ. Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. J Med Chem. 2006 Jan 12; 49(1):39-42.