"alpha Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Descriptor ID |
D028901
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MeSH Number(s) |
D12.776.157.530.750.500.100 D12.776.543.585.750.500.100 D12.776.660.502.100
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Concept/Terms |
alpha Karyopherins- alpha Karyopherins
- Karyopherins, alpha
- Karyopherin alpha
- Nuclear Localization Signal-Binding Protein
- NLS-Binding Protein
- NLSBP
- Nuclear Localization Sequence Receptor
- Importin-alpha
- NLS Receptor
- receptor, NLS
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Below are MeSH descriptors whose meaning is more general than "alpha Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "alpha Karyopherins".
This graph shows the total number of publications written about "alpha Karyopherins" by people in this website by year, and whether "alpha Karyopherins" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 1 | 0 | 1 |
2010 | 3 | 1 | 4 |
2011 | 2 | 0 | 2 |
2022 | 0 | 2 | 2 |
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click here.
Below are the most recent publications written about "alpha Karyopherins" by people in Profiles.
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Doll SG, Cingolani G. Importin a/? and the tug of war to keep TDP-43 in solution: quo vadis? Bioessays. 2022 12; 44(12):e2200181.
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Doll SG, Meshkin H, Bryer AJ, Li F, Ko YH, Lokareddy RK, Gillilan RE, Gupta K, Perilla JR, Cingolani G. Recognition of the TDP-43 nuclear localization signal by importin a1/ß. Cell Rep. 2022 Jun 28; 39(13):111007.
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Pumroy RA, Nardozzi JD, Hart DJ, Root MJ, Cingolani G. Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin a5. J Biol Chem. 2012 Jan 13; 287(3):2022-31.
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Lott K, Bhardwaj A, Sims PJ, Cingolani G. A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1. J Biol Chem. 2011 Aug 12; 286(32):28160-9.
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Mosca TJ, Schwarz TL. Drosophila Importin-a2 is involved in synapse, axon and muscle development. PLoS One. 2010 Dec 06; 5(12):e15223.
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Nardozzi J, Wenta N, Yasuhara N, Vinkemeier U, Cingolani G. Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol. 2010 Sep 10; 402(1):83-100.
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Mosca TJ, Schwarz TL. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci. 2010 Aug; 13(8):935-43.
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Lott K, Bhardwaj A, Mitrousis G, Pante N, Cingolani G. The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex. J Biol Chem. 2010 Apr 30; 285(18):13769-80.
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Chen MH, Ben-Efraim I, Mitrousis G, Walker-Kopp N, Sims PJ, Cingolani G. Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha. J Biol Chem. 2005 Mar 18; 280(11):10599-606.