beta Karyopherins

"beta Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.

Descriptor ID	D028961
MeSH Number(s)	D12.776.157.530.750.500.249 D12.776.543.585.750.500.249 D12.776.660.502.500
Concept/Terms	beta Karyopherins beta Karyopherins Karyopherins, beta Kap95 protein p92 nuclear protein nuclear protein, p92 beta Importins Importins, beta Karyopherin-beta Karyopherin-beta Subunit Karyopherin beta Subunit Importin-beta Importin beta Karyopherin beta

Below are MeSH descriptors whose meaning is more general than "beta Karyopherins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Nucleocytoplasmic Transport Proteins [D12.776.157.530.750]
Karyopherins [D12.776.157.530.750.500]
beta Karyopherins [D12.776.157.530.750.500.249]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Nucleocytoplasmic Transport Proteins [D12.776.543.585.750]
Karyopherins [D12.776.543.585.750.500]
beta Karyopherins [D12.776.543.585.750.500.249]
Nuclear Proteins [D12.776.660]
Karyopherins [D12.776.660.502]
beta Karyopherins [D12.776.660.502.500]

Below are MeSH descriptors whose meaning is related to "beta Karyopherins".

Below are MeSH descriptors whose meaning is more specific than "beta Karyopherins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta Karyopherins" by people in this website by year, and whether "beta Karyopherins" was a major or minor topic of these publications.

Bar chart showing 18 publications over 10 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	3	0	3
2008	1	0	1
2010	4	0	4
2011	0	1	1
2014	1	0	1
2015	1	1	2
2022	1	1	2
2024	2	0	2
2025	0	1	1

Below are the most recent publications written about "beta Karyopherins" by people in Profiles.

Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

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Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 09 10; 15(1):7887.

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Ko YH, Lokareddy RK, Doll SG, Yeggoni DP, Girdhar A, Mawn I, Klim JR, Rizvi NF, Meyers R, Gillilan RE, Guo L, Cingolani G. Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin a1/? Signaling. J Mol Biol. 2024 10 15; 436(20):168751.

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Doll SG, Meshkin H, Bryer AJ, Li F, Ko YH, Lokareddy RK, Gillilan RE, Gupta K, Perilla JR, Cingolani G. Recognition of the TDP-43 nuclear localization signal by importin a1/?. Cell Rep. 2022 06 28; 39(13):111007.

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Florio TJ, Lokareddy RK, Yeggoni DP, Sankhala RS, Ott CA, Gillilan RE, Cingolani G. Differential recognition of canonical NF-?B dimers by Importin a3. Nat Commun. 2022 03 08; 13(1):1207.

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Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EWK, Choi EY, Cingolani G, Weaver BA, Miyamoto S. IPO3-mediated Nonclassical Nuclear Import of NF-?B Essential Modulator (NEMO) Drives DNA Damage-dependent NF-?B Activation. J Biol Chem. 2015 Jul 17; 290(29):17967-17984.

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Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G. Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure. 2015 Jul 07; 23(7):1305-1316.

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Lieu KG, Shim EH, Wang J, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA. The p53-induced factor Ei24 inhibits nuclear import through an importin ?-binding-like domain. J Cell Biol. 2014 May 12; 205(3):301-12.

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Hoelz A, Debler EW, Blobel G. The structure of the nuclear pore complex. Annu Rev Biochem. 2011; 80:613-43.

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Lott K, Cingolani G. The importin ? binding domain as a master regulator of nucleocytoplasmic transport. Biochim Biophys Acta. 2011 Sep; 1813(9):1578-92.

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