GTP-Binding Protein alpha Subunits, Gq-G11

"GTP-Binding Protein alpha Subunits, Gq-G11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of heterotrimeric GTP-binding protein alpha subunits that activate TYPE C PHOSPHOLIPASES dependent signaling pathways. The Gq-G11 part of the name is also spelled Gq/G11.

Descriptor ID	D043802
MeSH Number(s)	D08.811.277.040.330.300.200.100.300 D12.644.360.360.100.300 D12.776.157.325.332.100.300 D12.776.476.375.100.300 D12.776.543.325.100.300
Concept/Terms	GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Protein alpha Subunits, Gq-G11 GTP Binding Protein alpha Subunits, Gq G11 Gq-G11 G-Proteins G-Proteins, Gq-G11 Gq G11 G Proteins Gq-G11 G-Protein Family Family, Gq-G11 G-Protein G-Protein Family, Gq-G11 Gq G11 G Protein Family G-Protein, Gq-G11 alpha Family G Protein, Gq G11 alpha Family G-Protein, Gq-G11 G Protein, Gq G11 Gq-G11 G-Protein GTP-Binding Protein alpha Subunit, Gq GTP-Binding Protein alpha Subunit, Gq GTP Binding Protein alpha Subunit, Gq G alpha q Protein Galphaq Protein G-Protein, Gq G Protein, Gq Gq G-Protein G-Protein, Gq alpha Family G Protein, Gq alpha Family G alpha Protein q Gq Protein GTP-Binding Protein alpha Subunit, G11 GTP-Binding Protein alpha Subunit, G11 GTP Binding Protein alpha Subunit, G11 G alpha11 Protein Protein, G alpha11 alpha11 Protein, G Galpha11 Protein Protein, Galpha11 G-Protein, G11 G Protein, G11 G11 G-Protein

Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, Gq-G11".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D08.811.277.040.330.300.200.100.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.644.360.360.100.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.157.325.332.100.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.476.375.100.300]
Membrane Proteins [D12.776.543]
Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.543.325.100.300]

Below are MeSH descriptors whose meaning is related to "GTP-Binding Protein alpha Subunits, Gq-G11".

Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, Gq-G11".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, Gq-G11" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, Gq-G11" was a major or minor topic of these publications.

Bar chart showing 24 publications over 17 distinct years, with a maximum of 3 publications in 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	1	1
2004	1	0	1
2005	1	1	2
2006	1	0	1
2007	1	0	1
2008	1	0	1
2009	1	0	1
2010	1	0	1
2011	1	2	3
2013	1	0	1
2017	0	3	3
2022	1	1	2
2023	0	2	2
2024	1	0	1

Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, Gq-G11" by people in Profiles.

Dimitriou F, Orloff MM, Koch Hein EC, Cheng PF, Hughes IF, Simeone E, Montazeri K, Grover P, Mehmi I, Gerard CL, Gaudy-Marqueste C, Grob JJ, Michielin O, Hamid O, Long GV, Sullivan R, Kapiteijn E, Johnson DB, Ascierto PA, Joshua AM, Carvajal RD, Butler MO, Hassel JC, Dummer R. Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors. Eur J Cancer. 2025 Jan; 214:115161.

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Wisinski KB, Flamand Y, Wilson MA, Luke JJ, Tawbi HA, Hong F, Mitchell EP, Zwiebel JA, Chen H, Gray RJ, Li S, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Behrens RJ, Pennington KP, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT. Trametinib in Patients With NF1-, GNAQ-, or GNA11-Mutant Tumors: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols S1 and S2. JCO Precis Oncol. 2023 Apr; 7:e2200421.

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Lapadula D, Lam B, Terai M, Sugase T, Tanaka R, Farias E, Kadamb R, Lopez-Anton M, Heine CC, Modasia B, Aguirre-Ghiso JA, Aplin AE, Sato T, Benovic JL. IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression. Mol Cancer Ther. 2023 01 03; 22(1):63-74.

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Randolph CE, Dwyer MB, Aumiller JL, Dixon AJ, Inoue A, Osei-Owusu P, Wedegaertner PB. Enhanced membrane binding of oncogenic G protein aqQ209L confers resistance to inhibitor YM-254890. J Biol Chem. 2022 11; 298(11):102538.

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Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC, Bastian BC, Bloomer MM, Pekmezci M. Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations. Ophthalmology. 2022 12; 129(12):1429-1439.

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Chien JL, Sioufi K, Surakiatchanukul T, Shields JA, Shields CL. Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. Curr Opin Ophthalmol. 2017 May; 28(3):228-237.

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Chandran SS, Somerville RPT, Yang JC, Sherry RM, Klebanoff CA, Goff SL, Wunderlich JR, Danforth DN, Zlott D, Paria BC, Sabesan AC, Srivastava AK, Xi L, Pham TH, Raffeld M, White DE, Toomey MA, Rosenberg SA, Kammula US. Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study. Lancet Oncol. 2017 06; 18(6):792-802.

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Cheng H, Chua V, Liao C, Purwin TJ, Terai M, Kageyama K, Davies MA, Sato T, Aplin AE. Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. Mol Cancer Ther. 2017 Mar; 16(3):516-528.

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Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One. 2013; 8(3):e57324.

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Zhang Y, Matkovich SJ, Duan X, Gold JI, Koch WJ, Dorn GW. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Circ Heart Fail. 2011 Sep; 4(5):659-68.

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