GTP-Binding Protein alpha Subunits, Gq-G11

"GTP-Binding Protein alpha Subunits, Gq-G11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of heterotrimeric GTP-binding protein alpha subunits that activate TYPE C PHOSPHOLIPASES dependent signaling pathways. The Gq-G11 part of the name is also spelled Gq/G11.

Descriptor ID	D043802
MeSH Number(s)	D08.811.277.040.330.300.200.100.300 D12.644.360.360.100.300 D12.776.157.325.332.100.300 D12.776.476.375.100.300 D12.776.543.325.100.300
Concept/Terms	GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Protein alpha Subunits, Gq-G11 GTP Binding Protein alpha Subunits, Gq G11 Gq-G11 G-Proteins G-Proteins, Gq-G11 Gq G11 G Proteins Gq-G11 G-Protein Family Family, Gq-G11 G-Protein G-Protein Family, Gq-G11 Gq G11 G Protein Family G-Protein, Gq-G11 alpha Family G Protein, Gq G11 alpha Family G-Protein, Gq-G11 G Protein, Gq G11 Gq-G11 G-Protein GTP-Binding Protein alpha Subunit, Gq GTP-Binding Protein alpha Subunit, Gq GTP Binding Protein alpha Subunit, Gq G alpha q Protein Galphaq Protein G-Protein, Gq G Protein, Gq Gq G-Protein G-Protein, Gq alpha Family G Protein, Gq alpha Family G alpha Protein q Gq Protein GTP-Binding Protein alpha Subunit, G11 GTP-Binding Protein alpha Subunit, G11 GTP Binding Protein alpha Subunit, G11 G alpha11 Protein Protein, G alpha11 alpha11 Protein, G Galpha11 Protein Protein, Galpha11 G-Protein, G11 G Protein, G11 G11 G-Protein

Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, Gq-G11".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D08.811.277.040.330.300.200.100.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.644.360.360.100.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.157.325.332.100.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.476.375.100.300]
Membrane Proteins [D12.776.543]
Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.543.325.100.300]

Below are MeSH descriptors whose meaning is related to "GTP-Binding Protein alpha Subunits, Gq-G11".

Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, Gq-G11".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, Gq-G11" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, Gq-G11" was a major or minor topic of these publications.

Bar chart showing 28 publications over 18 distinct years, with a maximum of 3 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	2	2
2003	0	1	1
2004	1	0	1
2006	2	0	2
2007	1	0	1
2008	2	0	2
2009	1	0	1
2011	1	1	2
2013	1	0	1
2014	1	1	2
2015	1	0	1
2017	1	2	3
2018	1	1	2
2021	1	0	1
2022	0	1	1
2023	0	2	2
2024	2	0	2

Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, Gq-G11" by people in Profiles.

Dimitriou F, Orloff MM, Koch Hein EC, Cheng PF, Hughes IF, Simeone E, Montazeri K, Grover P, Mehmi I, Gerard CL, Gaudy-Marqueste C, Grob JJ, Michielin O, Hamid O, Long GV, Sullivan R, Kapiteijn E, Johnson DB, Ascierto PA, Joshua AM, Carvajal RD, Butler MO, Hassel JC, Dummer R. Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors. Eur J Cancer. 2025 Jan; 214:115161.

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De Pascali F, Inoue A, Benovic JL. Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells. J Biol Chem. 2024 11; 300(11):107882.

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Baqai U, Kurimchak AM, Trachtenberg IV, Purwin TJ, Haj JI, Han A, Luo K, Pachon NF, Jeon A, Chua V, Davies MA, Gutkind JS, Benovic JL, Duncan JS, Aplin AE. Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma. J Biol Chem. 2023 12; 299(12):105418.

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Lapadula D, Lam B, Terai M, Sugase T, Tanaka R, Farias E, Kadamb R, Lopez-Anton M, Heine CC, Modasia B, Aguirre-Ghiso JA, Aplin AE, Sato T, Benovic JL. IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression. Mol Cancer Ther. 2023 01 03; 22(1):63-74.

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Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC, Bastian BC, Bloomer MM, Pekmezci M. Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations. Ophthalmology. 2022 12; 129(12):1429-1439.

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Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA, Penn RB, Kambayashi T, Deshpande DA. Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling. Am J Respir Cell Mol Biol. 2021 12; 65(6):658-671.

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Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2019 04; 17(4):963-973.

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Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1632-1643.

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Sundaram SK, Michelhaugh SK, Klinger NV, Kupsky WJ, Sood S, Chugani HT, Mittal S, Juh?sz C. GNAQ Mutation in the Venous Vascular Malformation and Underlying Brain Tissue in Sturge-Weber Syndrome. Neuropediatrics. 2017 10; 48(5):385-389.

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Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 05; 15(5):501-506.

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