Inhibitor of Apoptosis Proteins

"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Descriptor ID	D051034
MeSH Number(s)	D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
Concept/Terms	Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Apoptosis Proteins Inhibitor Inhibitor-Of-Apoptosis Protein Inhibitor Of Apoptosis Protein Baculoviral Inhibitor Of Apoptosis Repeat Proteins IAP Repeat Containing Proteins IAP Protein (Apoptosis) Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat Containing 2 Protein Cellular Inhibitor of Apoptosis 1 Protein IAP2 Protein c-IAP1 Protein cIAP1 Protein Inhibitor of Apoptosis 2 Protein BIRC2 Protein Baculoviral IAP Repeat Containing Protein 2

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Apoptosis Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".

Inhibitor of Apoptosis Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
X-Linked Inhibitor of Apoptosis Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.

Bar chart showing 41 publications over 20 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	3	3
1998	0	3	3
2000	0	2	2
2001	0	3	3
2003	0	2	2
2004	0	1	1
2005	0	2	2
2006	0	2	2
2007	0	1	1
2008	1	1	2
2009	0	2	2
2010	1	3	4
2012	1	2	3
2013	0	3	3
2015	1	1	2
2016	0	1	1
2017	0	1	1
2018	0	2	2
2023	0	1	1

Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.

Glasheen MQ, Caksa S, Young AG, Wilski NA, Ott CA, Chervoneva I, Flaherty KT, Herlyn M, Xu X, Aplin AE, Capparelli C. Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma. Mol Cancer Ther. 2023 09 05; 22(9):1087-1099.

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Rodrigue-Gervais IG, Doiron K, Champagne C, Mayes L, Leiva-Torres GA, Vani? P, Douglas T, Vidal SM, Alnemri ES, Saleh M. The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. Sci Rep. 2018 05 31; 8(1):8446.

View in: PubMed
Alturki NA, McComb S, Ariana A, Rijal D, Korneluk RG, Sun SC, Alnemri E, Sad S. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. Cell Death Dis. 2018 05 22; 9(6):592.

View in: PubMed
Gersey ZC, Rodriguez GA, Barbarite E, Sanchez A, Walters WM, Ohaeto KC, Komotar RJ, Graham RM. Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species. BMC Cancer. 2017 02 04; 17(1):99.

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Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol. 2016 07; 14(7):e1002507.

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Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA. A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. Mol Cancer Ther. 2015 Nov; 14(11):2569-75.

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Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal. 2015 Aug 11; 8(389):ra80.

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Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS. a6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14; 289(7):3842-55.

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Stearns V, Jacobs LK, Fackler M, Tsangaris TN, Rudek MA, Higgins M, Lange J, Cheng Z, Slater SA, Jeter SC, Powers P, Briest S, Chao C, Yoshizawa C, Sugar E, Espinoza-Delgado I, Sukumar S, Gabrielson E, Davidson NE. Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer. Clin Cancer Res. 2013 Jul 15; 19(14):4008-16.

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Gupta RK, Banerjee A, Pathak S, Sharma C, Singh N. Induction of mitochondrial-mediated apoptosis by Morinda citrifolia (Noni) in human cervical cancer cells. Asian Pac J Cancer Prev. 2013; 14(1):237-42.

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