Inhibitor of Apoptosis Proteins

"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Descriptor ID	D051034
MeSH Number(s)	D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
Concept/Terms	Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Apoptosis Proteins Inhibitor Inhibitor-Of-Apoptosis Protein Inhibitor Of Apoptosis Protein Baculoviral Inhibitor Of Apoptosis Repeat Proteins IAP Repeat Containing Proteins IAP Protein (Apoptosis) Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat Containing 2 Protein Cellular Inhibitor of Apoptosis 1 Protein IAP2 Protein c-IAP1 Protein cIAP1 Protein Inhibitor of Apoptosis 2 Protein BIRC2 Protein Baculoviral IAP Repeat Containing Protein 2

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Apoptosis Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".

Inhibitor of Apoptosis Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
X-Linked Inhibitor of Apoptosis Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.

Bar chart showing 26 publications over 15 distinct years, with a maximum of 3 publications in 1998 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	0	3	3
2000	0	1	1
2001	0	2	2
2003	0	2	2
2004	0	1	1
2005	0	2	2
2006	0	1	1
2008	1	1	2
2009	0	2	2
2010	1	2	3
2012	0	1	1
2013	0	2	2
2017	0	1	1

Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.

Gersey ZC, Rodriguez GA, Barbarite E, Sanchez A, Walters WM, Ohaeto KC, Komotar RJ, Graham RM. Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species. BMC Cancer. 2017 02 04; 17(1):99.

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Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS. a6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14; 289(7):3842-55.

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Stearns V, Jacobs LK, Fackler M, Tsangaris TN, Rudek MA, Higgins M, Lange J, Cheng Z, Slater SA, Jeter SC, Powers P, Briest S, Chao C, Yoshizawa C, Sugar E, Espinoza-Delgado I, Sukumar S, Gabrielson E, Davidson NE. Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer. Clin Cancer Res. 2013 Jul 15; 19(14):4008-16.

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Basu S, Rajakaruna S, Menko AS. Insulin-like growth factor receptor-1 and nuclear factor ?B are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2012 Mar 9; 287(11):8384-97.

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Zhang T, Fields JZ, Opdenaker L, Otevrel T, Masuda E, Palazzo JP, Isenberg GA, Goldstein SD, Brand M, Boman BM. Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. Am J Pathol. 2010 Dec; 177(6):2816-26.

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Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, Tanaka H, Pestell RG. C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell. 2010 Dec; 21(23):4264-74.

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Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, Altieri DC. IAP regulation of metastasis. Cancer Cell. 2010 Jan 19; 17(1):53-64.

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Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ, Otevrel T. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Mol Carcinog. 2009 Sep; 48(9):821-31.

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Guha M, Plescia J, Leav I, Li J, Languino LR, Altieri DC. Endogenous tumor suppression mediated by PTEN involves survivin gene silencing. Cancer Res. 2009 Jun 15; 69(12):4954-8.

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Fiskus W, Wang Y, Joshi R, Rao R, Yang Y, Chen J, Kolhe R, Balusu R, Eaton K, Lee P, Ustun C, Jillella A, Buser CA, Peiper S, Bhalla K. Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Clin Cancer Res. 2008 Oct 1; 14(19):6106-15.

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