"Munc18 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in intracellular membrane trafficking. They interact with SYNTAXINS and play important roles in vesicular docking and fusion during EXOCYTOSIS. Their name derives from the fact that they are related to Unc-18 protein, C elegans.
| Descriptor ID |
D051938
|
| MeSH Number(s) |
D12.776.543.990.587
|
| Concept/Terms |
Munc18 Proteins- Munc18 Proteins
- Syntaxin Binding Protein Munc18
- Sec1-Munc18 Protein Family
- Sec1 Munc18 Protein Family
- Munc-18 Proteins
- Munc 18 Proteins
- Munc18 Syntaxin Binding Proteins
|
Below are MeSH descriptors whose meaning is more general than "Munc18 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Munc18 Proteins".
This graph shows the total number of publications written about "Munc18 Proteins" by people in this website by year, and whether "Munc18 Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Munc18 Proteins" by people in Profiles.
-
Spessott WA, Sanmillan ML, McCormick ME, Kulkarni VV, Giraudo CG. SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2176-E2185.
-
Gburek-Augustat J, Beck-Woedl S, Tzschach A, Bauer P, Schoening M, Riess A. Epilepsy is not a mandatory feature of STXBP1 associated ataxia-tremor-retardation syndrome. Eur J Paediatr Neurol. 2016 Jul; 20(4):661-5.
-
Spessott WA, Sanmillan ML, McCormick ME, Patel N, Villanueva J, Zhang K, Nichols KE, Giraudo CG. Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion. Blood. 2015 Mar 05; 125(10):1566-77.
-
Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60.
-
Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell. 2007 Jan 12; 128(1):183-95.