Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
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| MeSH Number(s) |
D12.776.543.695
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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Chavez L, Meguro J, Chen S, de Paiva VN, Zambrano R, Eterno JM, Kumar R, Duncan MR, Benny M, Young KC, Dietrich WD, Brambilla R, Wu S, Schmidt AF. Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury. J Neuroinflammation. 2021 Dec 29; 18(1):310.
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Balta G, Topcuoglu S, Gursoy T, Gurgey A, Ovali F. Association of nonimmune hydrops fetalis with familial hemophagocytic lymphohistiocytosis in identical twin neonates with perforin His222Arg (c665A>G) mutation. J Pediatr Hematol Oncol. 2013 Nov; 35(8):e332-4.
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Remakus S, Sigal LJ. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response. J Virol. 2011 Dec; 85(23):12578-84.
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Parent MA, Berggren KN, Mullarky IK, Szaba FM, Kummer LW, Adamovicz JJ, Smiley ST. Yersinia pestis V protein epitopes recognized by CD4 T cells. Infect Immun. 2005 Apr; 73(4):2197-204.
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Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Res. 2004 Jul 15; 64(14):4965-72.
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Schmidt J, Rakocevic G, Raju R, Dalakas MC. Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity. Brain. 2004 May; 127(Pt 5):1182-90.
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Bowne WB, Srinivasan R, Wolchok JD, Hawkins WG, Blachere NE, Dyall R, Lewis JJ, Houghton AN. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med. 1999 Dec 06; 190(11):1717-22.
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Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM. Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.