NADPH Oxidases

"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.

Descriptor ID	D019255
MeSH Number(s)	D08.811.682.608.575 D12.776.331.894 D12.776.543.653
Concept/Terms	NADPH Oxidases NADPH Oxidases Oxidases, NADPH NAD(P)H oxidase NADPH Oxidase Oxidase, NADPH Nox Proteins NAD(P)H Oxidases

Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
NADH, NADPH Oxidoreductases [D08.811.682.608]
NADPH Oxidases [D08.811.682.608.575]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Flavoproteins [D12.776.331]
NADPH Oxidases [D12.776.331.894]
Membrane Proteins [D12.776.543]
NADPH Oxidases [D12.776.543.653]

Below are MeSH descriptors whose meaning is related to "NADPH Oxidases".

Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 4 publications in 2007 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	2	2
2004	1	0	1
2007	0	4	4
2008	0	1	1
2009	0	1	1
2010	0	1	1
2012	1	0	1
2013	0	1	1
2014	1	0	1
2015	4	0	4
2017	0	1	1
2018	1	0	1
2022	0	1	1

Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.

Kirkman DL, Ramick MG, Muth BJ, Stock JM, Townsend RR, Edwards DG. Sex differences in microvascular function and arterial hemodynamics in nondialysis chronic kidney disease. Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1130-H1136.

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Starke RM, Thompson JW, Ali MS, Pascale CL, Martinez Lege A, Ding D, Chalouhi N, Hasan DM, Jabbour P, Owens GK, Toborek M, Hare JM, Dumont AS. Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):610-621.

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Nastase MV, Janicova A, Wygrecka M, Schaefer L. Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling. Antioxid Redox Signal. 2017 Oct 20; 27(12):855-873.

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Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schr?der K, Brandes RP, Iozzo RV, Schaefer L. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1? synthesis. Matrix Biol. 2016 Jan; 49:61-81.

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Cowley AW, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension. 2016 Feb; 67(2):440-50.

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Cheng G, Lanza-Jacoby S. Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4. Biochem Biophys Res Commun. 2015 Sep 11; 465(1):41-6.

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Piera-Velazquez S, Jimenez SA. Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. Curr Rheumatol Rep. 2015 Jan; 17(1):473.

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DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol. 2014 Jun 15; 306(12):F1499-506.

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Hagler MA, Hadley TM, Zhang H, Mehra K, Roos CM, Schaff HV, Suri RM, Miller JD. TGF-? signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves. Cardiovasc Res. 2013 Jul 01; 99(1):175-84.

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Babelova A, Avaniadi D, Jung O, Fork C, Beckmann J, Kosowski J, Weissmann N, Anilkumar N, Shah AM, Schaefer L, Schr?der K, Brandes RP. Role of Nox4 in murine models of kidney disease. Free Radic Biol Med. 2012 Aug 15; 53(4):842-53.

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