Amyloid beta-Protein Precursor

"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Descriptor ID	D016564
MeSH Number(s)	D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
Concept/Terms	Amyloid beta-Protein Precursor Amyloid beta-Protein Precursor Amyloid beta Protein Precursor beta-Protein Precursor, Amyloid Amyloid beta Precursor Protein Protease Nexin II Nexin II, Protease beta-Amyloid Protein Precursor beta Amyloid Protein Precursor Protease Nexin 2 Nexin 2, Protease Amyloid A4 Protein Precursor Amyloid Protein Precursor

Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Amyloid beta-Protein Precursor [D12.776.049.407.249]
Membrane Proteins [D12.776.543]
Amyloid beta-Protein Precursor [D12.776.543.039]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Protease Nexins [D12.776.645.468]
Amyloid beta-Protein Precursor [D12.776.645.468.500]
Protein Precursors [D12.776.811]
Amyloid beta-Protein Precursor [D12.776.811.050]

Below are MeSH descriptors whose meaning is related to "Amyloid beta-Protein Precursor".

Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".

Amyloid beta-Protein Precursor
Amyloid beta-Peptides

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.

Bar chart showing 50 publications over 20 distinct years, with a maximum of 6 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	4	0	4
1998	4	0	4
1999	3	0	3
2000	2	4	6
2001	3	1	4
2002	0	1	1
2003	1	1	2
2005	2	0	2
2006	2	0	2
2008	2	1	3
2009	1	0	1
2010	0	3	3
2011	0	1	1
2012	2	2	4
2014	1	0	1
2015	1	1	2
2017	1	1	2
2018	0	2	2
2019	1	0	1

Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.

Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Amyloid-? plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC Neurosci. 2019 Mar 20; 20(1):13.

View in: PubMed
Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of A? amyloidosis. BMC Neurosci. 2018 07 28; 19(1):46.

View in: PubMed
Sen A, Hongpaisan J. Hippocampal microvasculature changes in association with oxidative stress in Alzheimer's disease. Free Radic Biol Med. 2018 05 20; 120:192-203.

View in: PubMed
Ross JA, Reyes BAS, Thomas SA, Van Bockstaele EJ. Localization of endogenous amyloid-? to the coeruleo-cortical pathway: consequences of noradrenergic depletion. Brain Struct Funct. 2018 Jan; 223(1):267-284.

View in: PubMed
Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ?-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol. 2017 Jan; 187(1):91-109.

View in: PubMed
Meeker KD, Meabon JS, Cook DG. Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 45(2):509-20.

View in: PubMed
Khanna MR, Fortini ME. Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-? Precursor-Like Protein Activity. J Alzheimers Dis. 2015; 46(4):913-28.

View in: PubMed
Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Kandelwal PJ, Kim FJ, Marenda DR, Saunders AJ. Cyclopamine modulates ?-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation. J Biol Chem. 2014 Nov 28; 289(48):33258-74.

View in: PubMed
Tanifum EA, Dasgupta I, Srivastava M, Bhavane RC, Sun L, Berridge J, Pourgarzham H, Kamath R, Espinosa G, Cook SC, Eriksen JL, Annapragada A. Intravenous delivery of targeted liposomes to amyloid-? pathology in APP/PSEN1 transgenic mice. PLoS One. 2012; 7(10):e48515.

View in: PubMed
Br?ck W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I. Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann Neurol. 2012 Sep; 72(3):385-94.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement