Inositol 1,4,5-Trisphosphate Receptors

"Inositol 1,4,5-Trisphosphate Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.

Descriptor ID	D053496
MeSH Number(s)	D12.776.157.530.400.150.760 D12.776.543.550.450.150.760 D12.776.543.585.400.150.760 D12.776.826.179
Concept/Terms	Inositol 1,4,5-Trisphosphate Receptors Inositol 1,4,5-Trisphosphate Receptors INSP3 Receptor Receptor, INSP3 IP3 Receptor Receptor, IP3 Inositol 1,4,5-Triphosphate Receptors Receptor, Inositol-1,4,5-triphosphate Inositol-1,4,5-Triphosphate Receptor 1,4,5-INTP Receptor Inositol Triphosphate Receptor Receptor, Inositol Triphosphate Triphosphate Receptor, Inositol Inositol 1,4,5-trisphosphate Receptor Type 1 Inositol 1,4,5-trisphosphate Receptor Type 1 INSP3 Receptor Type 1 Type 1 Inositol 1,4,5-trisphosphate Receptor Inositol 1,4,5-trisphosphate Receptor Type 2 Inositol 1,4,5-trisphosphate Receptor Type 2 INSP3 Receptor Type 2 Inositol 1,4,5-trisphosphate Receptor Type 3 Inositol 1,4,5-trisphosphate Receptor Type 3 Type 3 Inositol 1,4,5-trisphosphate Receptor INSP3 Receptor Type 3 Inositol 1,4,5-trisphosphate Receptor Subtype 3

Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate Receptors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Calcium Channels [D12.776.157.530.400.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Calcium Channels [D12.776.543.550.450.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Calcium Channels [D12.776.543.585.400.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.826.179]

Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate Receptors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate Receptors" was a major or minor topic of these publications.

Bar chart showing 28 publications over 15 distinct years, with a maximum of 4 publications in 2005 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	2	2
2003	0	3	3
2004	0	1	1
2005	1	3	4
2006	0	2	2
2007	3	0	3
2008	1	0	1
2009	1	0	1
2010	3	1	4
2011	0	2	2
2013	1	0	1
2015	1	0	1
2016	0	1	1
2019	1	0	1
2021	0	1	1

Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in Profiles.

Booth DM, Várnai P, Joseph SK, Hajnóczky G. Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER. Mol Cell. 2021 09 16; 81(18):3866-3876.e2.

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Brailoiu E, Chakraborty S, Brailoiu GC, Zhao P, Barr JL, Ilies MA, Unterwald EM, Abood ME, Taylor CW. Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors. Cell Rep. 2019 01 08; 26(2):330-337.e4.

View in: PubMed
Brailoiu E, Shipsky MM, Yan G, Abood ME, Brailoiu GC. Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. Brain Res. 2017 02 15; 1657:167-175.

View in: PubMed
Barr JL, Deliu E, Brailoiu GC, Zhao P, Yan G, Abood ME, Unterwald EM, Brailoiu E. Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways. Cell Calcium. 2015 Aug; 58(2):196-207.

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Alzayady KJ, Wagner LE, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI. Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 2013 Oct 11; 288(41):29772-84.

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Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gaq-mediated cell signaling. Circulation. 2011 Aug 2; 124(5):572-81.

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Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol. 2011 Sep; 301(3):C559-65.

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McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. J Neurosci. 2010 Jul 14; 30(28):9510-22.

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Anyatonwu G, Khan MT, Schug ZT, da Fonseca PC, Morris EP, Joseph SK. Calcium-dependent conformational changes in inositol trisphosphate receptors. J Biol Chem. 2010 Aug 6; 285(32):25085-93.

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Yule DI, Betzenhauser MJ, Joseph SK. Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis. Cell Calcium. 2010 Jun; 47(6):469-79.

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