"Protein Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
| Descriptor ID |
D054645
|
| MeSH Number(s) |
D08.811.277.352.650.625.687
|
| Concept/Terms |
Protein Phosphatase 1- Protein Phosphatase 1
- Protein Phosphatase-1
- Type 1 Serine Threonine Protein Phosphatase
- PP1c Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 1".
This graph shows the total number of publications written about "Protein Phosphatase 1" by people in this website by year, and whether "Protein Phosphatase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 3 | 3 |
| 2005 | 1 | 3 | 4 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 1" by people in Profiles.
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Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63.
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Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem. 2009 Dec 18; 284(51):35273-7.
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Freitas MR, Eto M, Kirkbride JA, Schott C, Sassard J, Stoclet JC. Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle. Fundam Clin Pharmacol. 2009 Apr; 23(2):169-78.
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Neppl RL, Lubomirov LT, Momotani K, Pfitzer G, Eto M, Somlyo AV. Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem. 2009 Mar 6; 284(10):6348-60.
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Eto M, Kirkbride J, Elliott E, Lo SH, Brautigan DL. Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. J Biol Chem. 2007 Jun 15; 282(24):17806-15.
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Patel CA, Rattan S. Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1747-56.
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Moore M, Shin ME, Bruning A, Schindler K, Vershon A, Winter E. Arg-Pro-X-Ser/Thr is a consensus phosphoacceptor sequence for the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae. Biochemistry. 2007 Jan 9; 46(1):271-8.
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Eto M, Brautigan DL. Assay for three-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2. Methods Mol Biol. 2007; 365:197-208.
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Patel CA, Rattan S. Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G830-7.
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Woodsome TP, Polzin A, Kitazawa K, Eto M, Kitazawa T. Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells. J Cell Sci. 2006 May 1; 119(Pt 9):1769-80.