"Decorin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
| Descriptor ID |
D058575
|
| MeSH Number(s) |
D09.698.735.700.750 D12.776.395.650.750.625 D12.776.395.650.875.500 D12.776.860.300.806.750
|
| Concept/Terms |
Decorin- Decorin
- Bone Proteoglycan II
- Proteoglycan II, Bone
- DSPG-II
|
Below are MeSH descriptors whose meaning is more general than "Decorin".
Below are MeSH descriptors whose meaning is more specific than "Decorin".
This graph shows the total number of publications written about "Decorin" by people in this website by year, and whether "Decorin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 7 | 7 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 7 | 7 |
| 2005 | 0 | 9 | 9 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 5 | 5 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 6 | 6 |
| 2010 | 2 | 2 | 4 |
| 2011 | 9 | 0 | 9 |
| 2012 | 4 | 1 | 5 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 2 | 1 | 3 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Decorin" by people in Profiles.
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Hua R, Han Y, Ni Q, Fajardo RJ, Iozzo RV, Ahmed R, Nyman JS, Wang X, Jiang JX. Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness. Bone Res. 2025 Jan 02; 13(1):2.
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Mondal DK, Xie C, Pascal GJ, Buraschi S, Iozzo RV. Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2317760121.
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Neill T, Xie C, Iozzo RV. Decorin evokes reversible mitochondrial depolarization in carcinoma and vascular endothelial cells. Am J Physiol Cell Physiol. 2022 11 01; 323(5):C1355-C1373.
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Lee N, Shi L, Colon Caraballo M, Nallasamy S, Mahendroo M, Iozzo RV, Myers K. Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy. J Biomech Eng. 2022 Jun 01; 144(6).
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Gupta S, Buyank F, Sinha NR, Grant DG, Sinha PR, Iozzo RV, Chaurasia SS, Mohan RR. Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo. Exp Eye Res. 2022 03; 216:108933.
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Schneider M, Dillinger AE, Ohlmann A, Iozzo RV, Fuchshofer R. Decorin-An Antagonist of TGF-ß in Astrocytes of the Optic Nerve. Int J Mol Sci. 2021 Jul 17; 22(14).
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Schaefer L, Dikic I. Autophagy: Instructions from the extracellular matrix. Matrix Biol. 2021 06; 100-101:1-8.
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Balne PK, Gupta S, Zhang J, Bristow D, Faubion M, Heil SD, Sinha PR, Green SL, Iozzo RV, Mohan RR. The functional role of decorin in corneal neovascularization in vivo. Exp Eye Res. 2021 06; 207:108610.
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Nastase MV, Janicova A, Roedig H, Hsieh LT, Wygrecka M, Schaefer L. Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin. J Histochem Cytochem. 2018 04; 66(4):261-272.
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Torres A, Gubbiotti MA, Iozzo RV. Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem. 2017 Mar 24; 292(12):5055-5069.