Decorin

"Decorin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

Descriptor ID	D058575
MeSH Number(s)	D09.698.735.700.750 D12.776.395.650.750.625 D12.776.395.650.875.500 D12.776.860.300.806.750
Concept/Terms	Decorin Decorin Bone Proteoglycan II Proteoglycan II, Bone DSPG-II

Below are MeSH descriptors whose meaning is more general than "Decorin".

Chemicals and Drugs [D]
Carbohydrates [D09]
Polysaccharides [D09.698]
Proteoglycans [D09.698.735]
Small Leucine-Rich Proteoglycans [D09.698.735.700]
Decorin [D09.698.735.700.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Proteoglycans [D12.776.395.650]
Chondroitin Sulfate Proteoglycans [D12.776.395.650.750]
Decorin [D12.776.395.650.750.625]
Small Leucine-Rich Proteoglycans [D12.776.395.650.875]
Decorin [D12.776.395.650.875.500]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
Small Leucine-Rich Proteoglycans [D12.776.860.300.806]
Decorin [D12.776.860.300.806.750]

Below are MeSH descriptors whose meaning is related to "Decorin".

Below are MeSH descriptors whose meaning is more specific than "Decorin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Decorin" by people in this website by year, and whether "Decorin" was a major or minor topic of these publications.

Bar chart showing 150 publications over 30 distinct years, with a maximum of 15 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	0	2	2
1998	0	4	4
1999	0	3	3
2000	0	4	4
2001	0	4	4
2002	0	7	7
2003	0	3	3
2004	0	7	7
2005	0	9	9
2006	0	6	6
2007	0	5	5
2008	0	4	4
2009	0	6	6
2010	2	2	4
2011	9	0	9
2012	7	1	8
2013	12	3	15
2014	5	0	5
2015	8	0	8
2016	4	0	4
2017	4	0	4
2018	2	1	3
2019	2	1	3
2020	3	1	4
2021	5	3	8
2022	2	2	4
2023	0	1	1
2024	2	0	2
2025	1	0	1

Below are the most recent publications written about "Decorin" by people in Profiles.

Hua R, Han Y, Ni Q, Fajardo RJ, Iozzo RV, Ahmed R, Nyman JS, Wang X, Jiang JX. Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness. Bone Res. 2025 Jan 02; 13(1):2.

View in: PubMed
Hjorth M, Egan CL, Telles GD, Pal M, Gallego-Ortega D, Fuller OK, McLennan ED, Gillis RD, Oh TG, Muscat GEO, Tegegne S, Mah MSM, Skhinas J, Estevez E, Adams TE, McKay MJ, Molloy M, Watt KI, Qian H, Gregorevic P, Cox TR, Hojman P, Midtgaard J, Christensen JF, Friedrichsen M, Iozzo RV, Sloan EK, Drew BG, Wojtaszewski JFP, Whitham M, Febbraio MA. Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice. J Sport Health Sci. 2025 Dec; 14:100991.

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Mondal DK, Xie C, Pascal GJ, Buraschi S, Iozzo RV. Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2317760121.

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Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabyan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2024 01; 125:88-99.

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Neill T, Xie C, Iozzo RV. Decorin evokes reversible mitochondrial depolarization in carcinoma and vascular endothelial cells. Am J Physiol Cell Physiol. 2022 11 01; 323(5):C1355-C1373.

View in: PubMed
Lee N, Shi L, Colon Caraballo M, Nallasamy S, Mahendroo M, Iozzo RV, Myers K. Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy. J Biomech Eng. 2022 06 01; 144(6).

View in: PubMed
Xie C, Mondal DK, Ulas M, Neill T, Iozzo RV. Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways. Am J Physiol Cell Physiol. 2022 03 01; 322(3):C554-C566.

View in: PubMed
Gupta S, Buyank F, Sinha NR, Grant DG, Sinha PR, Iozzo RV, Chaurasia SS, Mohan RR. Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo. Exp Eye Res. 2022 03; 216:108933.

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Colon-Caraballo M, Lee N, Nallasamy S, Myers K, Hudson D, Iozzo RV, Mahendroo M. Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy. Matrix Biol. 2022 01; 105:53-71.

View in: PubMed
Schneider M, Dillinger AE, Ohlmann A, Iozzo RV, Fuchshofer R. Decorin-An Antagonist of TGF-? in Astrocytes of the Optic Nerve. Int J Mol Sci. 2021 Jul 17; 22(14).

View in: PubMed

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