CTLA-4 Antigen

"CTLA-4 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.

Descriptor ID	D060908
MeSH Number(s)	D12.776.543.750.705.222.750 D23.050.301.264.894.158 D23.101.100.894.158
Concept/Terms	CTLA-4 Antigen CTLA-4 Antigen Antigen, CTLA-4 CTLA 4 Antigen Antigens, CD152 CD152 Antigens Cytotoxic T-Lymphocyte-Associated Antigen 4 Cytotoxic T Lymphocyte Associated Antigen 4 Cytotoxic T-Lymphocyte Antigen 4 Cytotoxic T Lymphocyte Antigen 4 CD152 Antigen Antigen, CD152

Below are MeSH descriptors whose meaning is more general than "CTLA-4 Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Costimulatory and Inhibitory T-Cell Receptors [D12.776.543.750.705.222]
CTLA-4 Antigen [D12.776.543.750.705.222.750]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
CTLA-4 Antigen [D23.050.301.264.894.158]
Biomarkers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
CTLA-4 Antigen [D23.101.100.894.158]

Below are MeSH descriptors whose meaning is more specific than "CTLA-4 Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CTLA-4 Antigen" by people in this website by year, and whether "CTLA-4 Antigen" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 4 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2003	0	1	1
2007	0	1	1
2008	0	3	3
2009	0	1	1
2010	0	1	1
2012	1	0	1
2015	1	1	2
2016	1	1	2
2017	2	2	4
2019	0	1	1
2023	0	1	1

Below are the most recent publications written about "CTLA-4 Antigen" by people in Profiles.

Jenkins KA, Park M, Pederzoli-Ribeil M, Eskiocak U, Johnson P, Guzman W, McLaughlin M, Moore-Lai D, O'Toole C, Liu Z, Nicholson B, Flesch V, Qiu H, Clackson T, O'Hagan RC, Rodeck U, Karow M, O'Neil J, Williams JC. XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer. 2023 12 12; 11(12).

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Goodman AM, Sokol ES, Frampton GM, Lippman SM, Kurzrock R. Microsatellite-Stable Tumors with High Mutational Burden Benefit from Immunotherapy. Cancer Immunol Res. 2019 10; 7(10):1570-1573.

View in: PubMed
Roviello G, Andre F, Venturini S, Pistilli B, Curigliano G, Cristofanilli M, Rosellini P, Generali D. Response rate as a potential surrogate for survival and efficacy in patients treated with novel immune checkpoint inhibitors: A meta-regression of randomised prospective studies. Eur J Cancer. 2017 11; 86:257-265.

View in: PubMed
Goodman AM, Kato S, Bazhenova L, Patel SP, Frampton GM, Miller V, Stephens PJ, Daniels GA, Kurzrock R. Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers. Mol Cancer Ther. 2017 11; 16(11):2598-2608.

View in: PubMed
Ramamurthy C, Godwin JL, Borghaei H. Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose? Curr Treat Options Oncol. 2017 Jun; 18(6):33.

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Hu ZI, Ho AY, McArthur HL. Combined Radiation Therapy and Immune Checkpoint Blockade Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys. 2017 09 01; 99(1):153-164.

View in: PubMed
Shields CL, Say EA, Mashayekhi A, Garg SJ, Dunn JP, Shields JA. Assessment of CTLA-4 Deficiency-Related Autoimmune Choroidopathy Response to Abatacept. JAMA Ophthalmol. 2016 07 01; 134(7):844-6.

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Nunnari G, Fagone P, Condorelli F, Nicoletti F, Malaguarnera L, Di Rosa M. CD4+ T-cell gene expression of healthy donors, HIV-1 and elite controllers: Immunological chaos. Cytokine. 2016 07; 83:127-135.

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Jie HB, Schuler PJ, Lee SC, Srivastava RM, Argiris A, Ferrone S, Whiteside TL, Ferris RL. CTLA-4? Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis. Cancer Res. 2015 Jun 01; 75(11):2200-10.

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Reese Z, Straubhar A, Pal SK, Agarwal N. Ipilimumab in the treatment of prostate cancer. Future Oncol. 2015; 11(1):27-37.

View in: PubMed

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