Acid Sensing Ion Channels
"Acid Sensing Ion Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.
| Descriptor ID |
D062565
|
| MeSH Number(s) |
D12.776.157.530.400.875.050 D12.776.543.550.450.875.050 D12.776.543.585.400.875.050 D12.776.631.024
|
| Concept/Terms |
Acid Sensing Ion Channels- Acid Sensing Ion Channels
- ASIC Channel
- Proton-Gated Sodium Channels
- Proton Gated Sodium Channels
- Sodium Channels, Proton-Gated
- Acid-Sensing Ion Channels
|
Below are MeSH descriptors whose meaning is more general than "Acid Sensing Ion Channels".
Below are MeSH descriptors whose meaning is more specific than "Acid Sensing Ion Channels".
This graph shows the total number of publications written about "Acid Sensing Ion Channels" by people in this website by year, and whether "Acid Sensing Ion Channels" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Acid Sensing Ion Channels" by people in Profiles.
-
Huque T, Cowart BJ, Dankulich-Nagrudny L, Pribitkin EA, Bayley DL, Spielman AI, Feldman RS, Mackler SA, Brand JG. Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One. 2009; 4(10):e7347.
-
Dwyer JM, Rizzo SJ, Neal SJ, Lin Q, Jow F, Arias RL, Rosenzweig-Lipson S, Dunlop J, Beyer CE. Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models. Psychopharmacology (Berl). 2009 Mar; 203(1):41-52.
-
Uchiyama Y, Guttapalli A, Gajghate S, Mochida J, Shapiro IM, Risbud MV. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res. 2008 Oct; 23(10):1619-28.
-
Arias RL, Sung ML, Vasylyev D, Zhang MY, Albinson K, Kubek K, Kagan N, Beyer C, Lin Q, Dwyer JM, Zaleska MM, Bowlby MR, Dunlop J, Monaghan M. Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiol Dis. 2008 Sep; 31(3):334-41.
-
Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. J Bone Miner Res. 2007 Dec; 22(12):1996-2006.