Amyotrophic Lateral Sclerosis

"Amyotrophic Lateral Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Descriptor ID	D000690
MeSH Number(s)	C10.228.854.139 C10.574.562.250 C10.574.950.050 C10.668.467.250 C18.452.845.800.050
Concept/Terms	Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Sclerosis, Amyotrophic Lateral Charcot Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis Lou Gehrig Disease Lou Gehrig's Disease Lou-Gehrigs Disease Disease, Lou-Gehrigs ALS (Amyotrophic Lateral Sclerosis) Gehrig's Disease Gehrig Disease Gehrigs Disease Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam Guam Form of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 Guam Disease Disease, Guam Amyotrophic Lateral Sclerosis With Dementia Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis

Below are MeSH descriptors whose meaning is more general than "Amyotrophic Lateral Sclerosis".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Spinal Cord Diseases [C10.228.854]
Amyotrophic Lateral Sclerosis [C10.228.854.139]
Neurodegenerative Diseases [C10.574]
Motor Neuron Disease [C10.574.562]
Amyotrophic Lateral Sclerosis [C10.574.562.250]
TDP-43 Proteinopathies [C10.574.950]
Amyotrophic Lateral Sclerosis [C10.574.950.050]
Neuromuscular Diseases [C10.668]
Motor Neuron Disease [C10.668.467]
Amyotrophic Lateral Sclerosis [C10.668.467.250]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Proteostasis Deficiencies [C18.452.845]
TDP-43 Proteinopathies [C18.452.845.800]
Amyotrophic Lateral Sclerosis [C18.452.845.800.050]

Below are MeSH descriptors whose meaning is more specific than "Amyotrophic Lateral Sclerosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyotrophic Lateral Sclerosis" by people in this website by year, and whether "Amyotrophic Lateral Sclerosis" was a major or minor topic of these publications.

Bar chart showing 96 publications over 24 distinct years, with a maximum of 10 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	0	2
2003	3	0	3
2004	1	0	1
2005	3	0	3
2006	6	1	7
2007	6	0	6
2008	4	0	4
2009	5	1	6
2010	6	1	7
2011	8	2	10
2012	3	0	3
2013	4	1	5
2014	2	1	3
2015	1	1	2
2016	3	1	4
2017	5	1	6
2018	2	1	3
2019	2	0	2
2020	1	1	2
2021	2	1	3
2022	6	0	6
2023	2	0	2
2024	4	1	5
2025	1	0	1

Below are the most recent publications written about "Amyotrophic Lateral Sclerosis" by people in Profiles.

Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

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Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes. EMBO Rep. 2024 May; 25(5):2479-2510.

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Arag?n-Gonz?lez A, Shaw AC, Kok JR, Roussel FS, Santos Souza CD, Granger SM, Vetter T, de Diego Y, Meyer KC, Beal SN, Shaw PJ, Ferraiuolo L. C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity. Fluids Barriers CNS. 2024 Apr 11; 21(1):34.

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Cheslow L, Snook AE, Waldman SA. Biomarkers for Managing Neurodegenerative Diseases. Biomolecules. 2024 Mar 26; 14(4).

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Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 2024 Jan 15; 12.

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Jensen BK. Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression. Adv Neurobiol. 2024; 39:285-318.

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Huang B, Liu X, Zhang T, Wu Q, Huang C, Xia XG, Zhou H. Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats. Int J Mol Sci. 2023 Nov 11; 24(22).

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Ilieva H, Vullaganti M, Kwan J. Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis. BMJ. 2023 10 27; 383:e075037.

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Doll SG, Cingolani G. Importin a/? and the tug of war to keep TDP-43 in solution: quo vadis? Bioessays. 2022 12; 44(12):e2200181.

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Alexander GM, Heiman-Patterson TD, Bearoff F, Sher RB, Hennessy L, Terek S, Caccavo N, Cox GA, Philip VM, Blankenhorn EA. Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease. PLoS One. 2022; 17(9):e0274615.

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