Arachidonate 5-Lipoxygenase
"Arachidonate 5-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
| Descriptor ID |
D001094
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| MeSH Number(s) |
D08.811.682.690.416.583.500.055 D12.776.556.579.374.568.500.020
|
| Concept/Terms |
Arachidonate 5-Lipoxygenase- Arachidonate 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonate
- Arachidonate 5 Lipoxygenase
- Arachidonic Acid 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 5 Lipoxygenase
- LTA4 Synthase
- Synthase, LTA4
- Leukotriene A4 Synthase
- Synthase, Leukotriene A4
- Leukotriene A4 Synthetase
- Synthetase, Leukotriene A4
- 5-Lipoxygenase
- 5 Lipoxygenase
- Leukotriene A Synthase
- Synthase, Leukotriene A
|
Below are MeSH descriptors whose meaning is more general than "Arachidonate 5-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 5-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Arachidonate 5-Lipoxygenase" by people in Profiles.
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Ball AK, Beilstein K, Wittmann S, S?r?n D, Saul MJ, Schn?tgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, H?fner AK, Steinhilber D. Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LO?13, 5-LO?4 and 5-LOp12. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May; 1862(5):561-571.
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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.
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de Godoy MA, Rattan N, Rattan S. Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G727-34.
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Melstrom LG, Bentrem DJ, Salabat MR, Kennedy TJ, Ding XZ, Strouch M, Rao SM, Witt RC, Ternent CA, Talamonti MS, Bell RH, Adrian TA. Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Cancer Res. 2008 Oct 15; 14(20):6525-30.
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Tong WG, Ding XZ, Talamonti MS, Bell RH, Adrian TE. LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):949-56.
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Hennig R, Grippo P, Ding XZ, Rao SM, Buchler MW, Friess H, Talamonti MS, Bell RH, Adrian TE. 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Cancer Res. 2005 Jul 15; 65(14):6011-6.
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Kane GC, Tollino M, Pollice M, Kim CJ, Cohn J, Murray JJ, Dworski R, Sheller J, Fish JE, Peters SP. Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. Prostaglandins. 1995 Jul; 50(1):1-18.