C-Peptide

"C-Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.

Descriptor ID	D002096
MeSH Number(s)	D06.472.699.587.200.500.250 D12.644.548.586.200.500.250
Concept/Terms	C-Peptide C-Peptide C Peptide Connecting Peptide Proinsulin C-Peptide Proinsulin C Peptide C-Peptide, Proinsulin C Peptide, Proinsulin

Below are MeSH descriptors whose meaning is more general than "C-Peptide".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Pancreatic Hormones [D06.472.699.587]
Insulins [D06.472.699.587.200]
Proinsulin [D06.472.699.587.200.500]
C-Peptide [D06.472.699.587.200.500.250]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Hormones [D12.644.548]
Pancreatic Hormones [D12.644.548.586]
Insulins [D12.644.548.586.200]
Proinsulin [D12.644.548.586.200.500]
C-Peptide [D12.644.548.586.200.500.250]

Below are MeSH descriptors whose meaning is related to "C-Peptide".

Below are MeSH descriptors whose meaning is more specific than "C-Peptide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "C-Peptide" by people in this website by year, and whether "C-Peptide" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2009 and 2012 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2003	0	1	1
2005	1	0	1
2006	0	1	1
2008	0	1	1
2009	2	0	2
2010	1	0	1
2011	0	1	1
2012	0	2	2
2016	0	1	1
2020	0	1	1
2024	1	1	2

Below are the most recent publications written about "C-Peptide" by people in Profiles.

Qian F, Guo Y, Li C, Liu Y, Luttmann-Gibson H, Gomelskaya N, Demler OV, Cook NR, Lee IM, Buring JE, Larsen J, Boring J, McPhaul MJ, Manson JE, Pradhan AD, Mora S. Biomarkers of glucose-insulin homeostasis and incident type 2 diabetes and cardiovascular disease: results from the Vitamin D and Omega-3 trial. Cardiovasc Diabetol. 2024 11 02; 23(1):393.

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Wright JL, Schenk JM, Gulati R, Beatty SJ, VanDoren M, Lin DW, Porter MP, Morrissey C, Dash A, Gore JL, Etzioni R, Plymate SR, Neuhouser ML. The Prostate Cancer Active Lifestyle Study (PALS): A randomized controlled trial of diet and exercise in overweight and obese men on active surveillance. Cancer. 2024 Jun 15; 130(12):2108-2119.

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Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Pollak MN, Nixon AB, Mullen BC, O'Neil BH, Shaw JE, Polite BN, Benson AB, Atkins JN, Goldberg RM, Brown JC, O'Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA. IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. JNCI Cancer Spectr. 2021 02; 5(1).

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Hansen M, Scheltema MJ, Sonne DP, Hansen JS, Sperling M, Rehfeld JF, Holst JJ, Vilsb?ll T, Knop FK. Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion. Diabetes Obes Metab. 2016 06; 18(6):571-80.

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Costantine MM, Mele L, Landon MB, Spong CY, Ramin SM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp JM, Sciscione A, Catalano P, Caritis SN, Sorokin Y, Peaceman AM, Tolosa JE, Anderson GD. Customized versus population approach for evaluation of fetal overgrowth. Am J Perinatol. 2013 Aug; 30(7):565-72.

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Wouters EF, Bredenbr?ker D, Teichmann P, Brose M, Rabe KF, Fabbri LM, G?ke B. Effect of the phosphodiesterase 4 inhibitor roflumilast on glucose metabolism in patients with treatment-naive, newly diagnosed type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1720-5.

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Durnwald CP, Mele L, Spong CY, Ramin SM, Varner MW, Rouse DJ, Sciscione A, Catalano P, Saade G, Sorokin Y, Tolosa JE, Casey B, Anderson GD. Glycemic characteristics and neonatal outcomes of women treated for mild gestational diabetes. Obstet Gynecol. 2011 Apr; 117(4):819-827.

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Fasano CJ, Rowden AK, O'Malley GF, Aguilera E, Heard K. Quantitative insulin and C-peptide levels among ED patients with sulfonylurea-induced hypoglycemia-a prospective case series. Am J Emerg Med. 2010 Oct; 28(8):952-5.

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Schenk JM, Kristal AR, Neuhouser ML, Tangen CM, White E, Lin DW, Thompson IM. Serum adiponectin, C-peptide and leptin and risk of symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial. Prostate. 2009 Sep 01; 69(12):1303-11.

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Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ. C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience. 2009 Mar 17; 159(2):492-500.

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