Cholesterol Side-Chain Cleavage Enzyme
"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
| Descriptor ID |
D002786
|
| MeSH Number(s) |
D08.244.453.484.250 D08.244.453.915.212 D08.811.682.690.708.170.425.250 D08.811.682.690.708.170.915.212 D12.776.422.220.453.484.250 D12.776.422.220.453.915.212
|
| Concept/Terms |
Cholesterol Side-Chain Cleavage Enzyme- Cholesterol Side-Chain Cleavage Enzyme
- Cholesterol Side Chain Cleavage Enzyme
- Cholesterol Desmolase
- Cytochrome P-450(scc)
- CYP11A1
- CYP 11A1
- Cytochrome P450 11A1
- Cytochrome P-450 CYP11A1
- Cytochrome P 450 CYP11A1
- Cholesterol Monooxygenase (Side-Chain-Cleaving)
- 20,22-Desmolase
- 20,22 Desmolase
- Cytochrome P450scc
|
Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".
This graph shows the total number of publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in this website by year, and whether "Cholesterol Side-Chain Cleavage Enzyme" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in Profiles.
-
Tong ZB, Otsuka N, Tu W, Wei Q, DeCherney AH. P450 Side-Chain Cleavage Enzyme (P450-SCC) Is an Ovarian Autoantigen in a Mouse Model for Autoimmune Oophoritis. Reprod Sci. 2022 08; 29(8):2391-2400.
-
Kallen CB. Steroid hormone synthesis in pregnancy. Obstet Gynecol Clin North Am. 2004 Dec; 31(4):795-816, x.
-
Nair AK, Kash JC, Peegel H, Menon KM. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J Biol Chem. 2002 Jun 14; 277(24):21468-73.
-
Pena P, Reutens AT, Albanese C, D'Amico M, Watanabe G, Donner A, Shu IW, Williams T, Pestell RG. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol. 1999 Aug; 13(8):1402-16.
-
Pestell RG, Albanese C, Watanabe G, Lee RJ, Lastowiecki P, Zon L, Ostrowski M, Jameson JL. Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Mol Endocrinol. 1996 Sep; 10(9):1084-94.
-
Pestell RG, Albanese C, Watanabe G, Johnson J, Eklund N, Lastowiecki P, Jameson JL. Epidermal growth factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter. J Biol Chem. 1995 Aug 4; 270(31):18301-8.