"DNA Restriction Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Descriptor ID |
D004262
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MeSH Number(s) |
D08.811.150.280 D08.811.277.352.335.350.300 D08.811.277.352.355.325.300
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Concept/Terms |
DNA Restriction Enzymes- DNA Restriction Enzymes
- Enzymes, DNA Restriction
- Restriction Enzymes, DNA
- Restriction Endonucleases
- Endonucleases, Restriction
- Restriction Endonuclease
- Endonuclease, Restriction
- DNA Restriction Enzyme
- Restriction Enzyme, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Restriction Enzymes".
Below are MeSH descriptors whose meaning is more specific than "DNA Restriction Enzymes".
This graph shows the total number of publications written about "DNA Restriction Enzymes" by people in this website by year, and whether "DNA Restriction Enzymes" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1996 | 1 | 2 | 3 |
1997 | 1 | 0 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Restriction Enzymes" by people in Profiles.
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Jenkins FJ, Kerr CM, Fouquerel E, Bovbjerg DH, Opresko PL. Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization. J Vis Exp. 2017 07 10; (125).
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Luo P, Tsang TC, Takeuchi C, Dekker J, Badowski M, Harris DT. High-efficiency cloning system for versatile adaptation of DNA fragments. Biotechniques. 2002 Oct; 33(4):738, 740, 742.
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Aho S, Rothenberger K, Tan EM, Ryoo YW, Cho BH, McLean WH, Uitto J. Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements. Genomics. 1999 Mar 01; 56(2):160-8.
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Chow JW, Donabedian SM, Clewell DB, Sahm DF, Zervos MJ. In vitro susceptibility and molecular analysis of gentamicin-resistant enterococci. Diagn Microbiol Infect Dis. 1998 Nov; 32(3):141-6.
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Cheong N, Iliakis G. In vitro rejoining of double strand breaks induced in cellular DNA by bleomycin and restriction endonucleases. Int J Radiat Biol. 1997 Apr; 71(4):365-75.
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Jiang XM, Arepally G, Poncz M, McKenzie SE. Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). J Immunol Methods. 1996 Nov 29; 199(1):55-9.
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Hobson GM, Harlow PP, Benfield PA. Construction of linker-scanning mutations by oligonucleotide ligation. Methods Mol Biol. 1996; 57:279-85.
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Harlow PP, Hobson GM, Benfield PA. Construction of linker-scanning mutations using PCR. Methods Mol Biol. 1996; 57:287-95.
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Kinashi Y, Okayasu R, Iliakis GE, Nagasawa H, Little JB. Induction of DNA double-strand breaks by restriction enzymes in X-ray-sensitive mutant Chinese hamster ovary cells measured by pulsed-field gel electrophoresis. Radiat Res. 1995 Feb; 141(2):153-9.
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Mermelstein LD, Papoutsakis ET. In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol. 1993 Apr; 59(4):1077-81.