"DNA Restriction Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
| Descriptor ID |
D004262
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| MeSH Number(s) |
D08.811.150.280 D08.811.277.352.335.350.300 D08.811.277.352.355.325.300
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| Concept/Terms |
DNA Restriction Enzymes- DNA Restriction Enzymes
- Enzymes, DNA Restriction
- Restriction Enzymes, DNA
- Restriction Endonucleases
- Endonucleases, Restriction
- Restriction Endonuclease
- Endonuclease, Restriction
- DNA Restriction Enzyme
- Restriction Enzyme, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Restriction Enzymes".
Below are MeSH descriptors whose meaning is more specific than "DNA Restriction Enzymes".
This graph shows the total number of publications written about "DNA Restriction Enzymes" by people in this website by year, and whether "DNA Restriction Enzymes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Restriction Enzymes" by people in Profiles.
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Jenkins FJ, Kerr CM, Fouquerel E, Bovbjerg DH, Opresko PL. Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization. J Vis Exp. 2017 07 10; (125).
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Mermelstein LD, Papoutsakis ET. In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol. 1993 Apr; 59(4):1077-81.
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Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 1990 Jul 15; 76(2):336-44.
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Sharon B, Poncz M, Surrey S, Schwartz E. Non-random association of the Rsa I polymorphic site 5' to the beta-globin gene with major sickle cell haplotypes. Hemoglobin. 1988; 12(2):115-24.
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Flomenberg PR, Chen M, Munk G, Horwitz MS. Molecular epidemiology of adenovirus type 35 infections in immunocompromised hosts. J Infect Dis. 1987 Jun; 155(6):1127-34.
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Guzzo C, Weiner M, Rappaport E, LaRocco P, Surrey S, Poncz M, Schwartz E. An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene. Nucleic Acids Res. 1987 Jan 12; 15(1):380.
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Valderrama-Leon G, Flomenberg P, Horwitz MS. Restriction endonuclease mapping of adenovirus 35, a type isolated from immunocompromised hosts. J Virol. 1985 Nov; 56(2):647-50.
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Rappaport EF, Schwartz E, Poncz M, Surrey S. Frequent occurrence of a zeta-globin-region deletion in American blacks accounts for a previously-described restriction site polymorphism. Biochem Biophys Res Commun. 1984 Dec 14; 125(2):817-23.
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Semenza GL, Malladi P, Surrey S, Delgrosso K, Poncz M, Schwartz E. Detection of a novel DNA polymorphism in the beta-globin gene cluster. J Biol Chem. 1984 May 25; 259(10):6045-8.
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Balsley JF, Rappaport E, Schwartz E, Surrey S. The gamma-delta-beta-globin gene region in G gamma-beta +-hereditary persistence of fetal hemoglobin. Blood. 1982 Apr; 59(4):828-31.