"Gene Conversion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The asymmetrical segregation of genes during replication which leads to the production of non-reciprocal recombinant strands and the apparent conversion of one allele into another. Thus, e.g., the meiotic products of an Aa individual may be AAAa or aaaA instead of AAaa, i.e., the A allele has been converted into the a allele or vice versa.
| Descriptor ID |
D005785
|
| MeSH Number(s) |
G05.728.615.475
|
| Concept/Terms |
Gene Conversion- Gene Conversion
- Conversion, Gene
- Conversions, Gene
- Gene Conversions
Polar Recombination- Polar Recombination
- Polar Recombinations
- Recombination, Polar
- Recombinations, Polar
|
Below are MeSH descriptors whose meaning is more general than "Gene Conversion".
Below are MeSH descriptors whose meaning is more specific than "Gene Conversion".
This graph shows the total number of publications written about "Gene Conversion" by people in this website by year, and whether "Gene Conversion" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Conversion" by people in Profiles.
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Stabley DL, Holbrook J, Scavina M, Crawford TO, Swoboda KJ, Robbins KM, Butchbach MER. Detection of SMN1 to SMN2 gene conversion events and partial SMN1 gene deletions using array digital PCR. Neurogenetics. 2021 03; 22(1):53-64.
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Willis NA, Chandramouly G, Huang B, Kwok A, Follonier C, Deng C, Scully R. BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature. 2014 Jun 26; 510(7506):556-9.
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Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R. BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids. Nat Commun. 2013; 4:2404.
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Nagaraju G, Hartlerode A, Kwok A, Chandramouly G, Scully R. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol. 2009 Aug; 29(15):4283-94.
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Yoon K, Igoucheva O, Alexeev V. Expectations and reality in gene repair. Nat Biotechnol. 2002 Dec; 20(12):1197-8.
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Gamper HB, Parekh H, Rice MC, Bruner M, Youkey H, Kmiec EB. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Res. 2000 Nov 01; 28(21):4332-9.
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Alexeev V, Igoucheva O, Domashenko A, Cotsarelis G, Yoon K. Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide. Nat Biotechnol. 2000 Jan; 18(1):43-7.
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Giusti AM, Manser T. Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion. J Exp Med. 1994 Jan 01; 179(1):235-48.
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Kim HS, Lyons KM, Saitoh E, Azen EA, Smithies O, Maeda N. The structure and evolution of the human salivary proline-rich protein gene family. Mamm Genome. 1993; 4(1):3-14.
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Shiokawa S, Fucharoen S, Fucharoen G, Tomatsu S, Fukumaki Y. Heterogeneity of the gamma-globin gene sequences in Japanese individuals: implication of gene conversion in generation of polymorphisms. J Biochem. 1989 Feb; 105(2):184-9.