Genes, ras

"Genes, ras" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Descriptor ID	D011905
MeSH Number(s)	G05.360.340.024.340.375.500.791.550
Concept/Terms	Genes, ras Genes, ras ras Genes ras Gene N-ras Genes N-ras Genes Genes, N-ras N ras Genes N-ras Gene N-ras Oncogenes N ras Oncogenes N-ras Oncogene v-H-ras Oncogenes v-H-ras Oncogenes v H ras Oncogenes v-H-ras Oncogene v-Ha-ras Genes v-Ha-ras Genes Gene, v-Ha-ras Genes, v-Ha-ras v Ha ras Genes v-Ha-ras Gene v-Ha-ras Oncogenes v-Ha-ras Oncogenes v Ha ras Oncogenes v-Ha-ras Oncogene v-K-ras Genes v-K-ras Genes v K ras Genes v-K-ras Gene v-K-ras Oncogenes v-K-ras Oncogenes v K ras Oncogenes v-K-ras Oncogene v-Ki-ras Genes v-Ki-ras Genes Gene, v-Ki-ras Genes, v-Ki-ras v Ki ras Genes v-Ki-ras Gene v-Ki-ras Oncogenes v-Ki-ras Oncogenes v Ki ras Oncogenes v-Ki-ras Oncogene c-H-ras Genes c-H-ras Genes c H ras Genes c-H-ras Gene c-H-ras Proto-Oncogenes c-H-ras Proto-Oncogenes c H ras Proto Oncogenes c-H-ras Proto-Oncogene c-Ha-ras Genes c-Ha-ras Genes c Ha ras Genes c-Ha-ras Gene Ha-ras Oncogenes Ha-ras Oncogenes Ha ras Oncogenes Ha-ras Oncogene c-Ha-ras Proto-Oncogenes c-Ha-ras Proto-Oncogenes c Ha ras Proto Oncogenes c-Ha-ras Proto-Oncogene c-K-ras Genes c-K-ras Genes c K ras Genes c-K-ras Gene c-K-ras Proto-Oncogenes c-K-ras Proto-Oncogenes c K ras Proto Oncogenes c-K-ras Proto-Oncogene c-Ki-ras Genes c-Ki-ras Genes c Ki ras Genes c-Ki-ras Gene c-Ki-ras Proto-Oncogenes c-Ki-ras Proto-Oncogenes c Ki ras Proto Oncogenes c-Ki-ras Proto-Oncogene c-N-ras Genes c-N-ras Genes c N ras Genes c-N-ras Gene c-N-ras Proto-Oncogenes c-N-ras Proto-Oncogenes c N ras Proto Oncogenes c-N-ras Proto-Oncogene H-ras Genes H-ras Genes H ras Genes H-ras Gene H-ras Oncogenes H-ras Oncogenes H ras Oncogenes H-ras Oncogene Ha-ras Genes Ha-ras Genes Gene, Ha-ras Genes, Ha-ras Ha ras Genes Ha-ras Gene K-ras Genes K-ras Genes K ras Genes K-ras Gene K-ras Oncogenes K-ras Oncogenes K ras Oncogenes K-ras Oncogene Ki-ras Genes Ki-ras Genes Gene, Ki-ras Genes, Ki-ras Ki ras Genes Ki-ras Gene Ki-ras Oncogenes Ki-ras Oncogenes Ki ras Oncogenes Ki-ras Oncogene ras Oncogene ras Oncogene ras Oncogenes v-H-ras Genes v-H-ras Genes v H ras Genes v-H-ras Gene

Below are MeSH descriptors whose meaning is more general than "Genes, ras".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Oncogenes [G05.360.340.024.340.375.500]
Proto-Oncogenes [G05.360.340.024.340.375.500.791]
Genes, ras [G05.360.340.024.340.375.500.791.550]

Below are MeSH descriptors whose meaning is related to "Genes, ras".

Below are MeSH descriptors whose meaning is more specific than "Genes, ras".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, ras" by people in this website by year, and whether "Genes, ras" was a major or minor topic of these publications.

Bar chart showing 83 publications over 24 distinct years, with a maximum of 6 publications in 1995 and 1998 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	4	2	6
1996	2	2	4
1997	1	4	5
1998	4	2	6
1999	0	3	3
2000	2	3	5
2001	2	2	4
2002	3	1	4
2003	1	4	5
2004	2	1	3
2005	1	3	4
2006	1	5	6
2007	1	4	5
2008	3	0	3
2009	2	0	2
2010	1	1	2
2011	1	2	3
2012	1	3	4
2013	0	2	2
2014	1	0	1
2015	0	1	1
2017	1	2	3
2018	1	0	1
2019	0	1	1

Below are the most recent publications written about "Genes, ras" by people in Profiles.

McCallen LM, Ameduri RK, Denfield SW, Dodd DA, Everitt MD, Johnson JN, Lee TM, Lin AE, Lohr JL, May LJ, Pierpont ME, Stevenson DA, Chatfield KC. Cardiac transplantation in children with Noonan syndrome. Pediatr Transplant. 2019 09; 23(6):e13535.

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Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018 05 08; 9(1):1816.

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Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Fruth B, Meyerhardt JA, Schrag D, Greene C, O'Neil BH, Atkins JN, Berry S, Polite BN, O'Reilly EM, Goldberg RM, Hochster HS, Schilsky RL, Bertagnolli MM, El-Khoueiry AB, Watson P, Benson AB, Mulkerin DL, Mayer RJ, Blanke C. Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA. 2017 06 20; 317(23):2392-2401.

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Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED, D'Agostino RB, Petro RM, Blackstock W, Powell BL, Abraham E, Pasche B, Zhang W. Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. J Hematol Oncol. 2017 May 04; 10(1):100.

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Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 03 09; 2(5):e91225.

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Gripp KW, Sol-Church K, Smpokou P, Graham GE, Stevenson DA, Hanson H, Viskochil DH, Baker LC, Russo B, Gardner N, Stabley DL, Kolbe V, Rosenberger G. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences. Am J Med Genet A. 2015 Sep; 167A(9):2085-97.

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Zhu B, Ferry CH, Markell LK, Blazanin N, Glick AB, Gonzalez FJ, Peters JM. The nuclear receptor peroxisome proliferator-activated receptor-?/d (PPAR?/d) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. J Biol Chem. 2014 Jul 18; 289(29):20102-19.

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Jain N, Curran E, Iyengar NM, Diaz-Flores E, Kunnavakkam R, Popplewell L, Kirschbaum MH, Karrison T, Erba HP, Green M, Poire X, Koval G, Shannon K, Reddy PL, Joseph L, Atallah EL, Dy P, Thomas SP, Smith SE, Doyle LA, Stadler WM, Larson RA, Stock W, Odenike O. Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial. Clin Cancer Res. 2014 Jan 15; 20(2):490-8.

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Garrett CR, Bekaii-Saab TS, Ryan T, Fisher GA, Clive S, Kavan P, Shacham-Shmueli E, Buchbinder A, Goldberg RM. Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer. Cancer. 2013 Dec 15; 119(24):4223-30.

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Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012 Nov 15; 72(22):5966-75.

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