Genes, ras

"Genes, ras" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Descriptor ID	D011905
MeSH Number(s)	G05.360.340.024.340.375.500.791.550
Concept/Terms	Genes, ras Genes, ras ras Genes ras Gene N-ras Genes N-ras Genes Genes, N-ras N ras Genes N-ras Gene N-ras Oncogenes N ras Oncogenes N-ras Oncogene v-H-ras Oncogenes v-H-ras Oncogenes v H ras Oncogenes v-H-ras Oncogene v-Ha-ras Genes v-Ha-ras Genes Gene, v-Ha-ras Genes, v-Ha-ras v Ha ras Genes v-Ha-ras Gene v-Ha-ras Oncogenes v-Ha-ras Oncogenes v Ha ras Oncogenes v-Ha-ras Oncogene v-K-ras Genes v-K-ras Genes v K ras Genes v-K-ras Gene v-K-ras Oncogenes v-K-ras Oncogenes v K ras Oncogenes v-K-ras Oncogene v-Ki-ras Genes v-Ki-ras Genes Gene, v-Ki-ras Genes, v-Ki-ras v Ki ras Genes v-Ki-ras Gene v-Ki-ras Oncogenes v-Ki-ras Oncogenes v Ki ras Oncogenes v-Ki-ras Oncogene c-H-ras Genes c-H-ras Genes c H ras Genes c-H-ras Gene c-H-ras Proto-Oncogenes c-H-ras Proto-Oncogenes c H ras Proto Oncogenes c-H-ras Proto-Oncogene c-Ha-ras Genes c-Ha-ras Genes c Ha ras Genes c-Ha-ras Gene Ha-ras Oncogenes Ha-ras Oncogenes Ha ras Oncogenes Ha-ras Oncogene c-Ha-ras Proto-Oncogenes c-Ha-ras Proto-Oncogenes c Ha ras Proto Oncogenes c-Ha-ras Proto-Oncogene c-K-ras Genes c-K-ras Genes c K ras Genes c-K-ras Gene c-K-ras Proto-Oncogenes c-K-ras Proto-Oncogenes c K ras Proto Oncogenes c-K-ras Proto-Oncogene c-Ki-ras Genes c-Ki-ras Genes c Ki ras Genes c-Ki-ras Gene c-Ki-ras Proto-Oncogenes c-Ki-ras Proto-Oncogenes c Ki ras Proto Oncogenes c-Ki-ras Proto-Oncogene c-N-ras Genes c-N-ras Genes c N ras Genes c-N-ras Gene c-N-ras Proto-Oncogenes c-N-ras Proto-Oncogenes c N ras Proto Oncogenes c-N-ras Proto-Oncogene H-ras Genes H-ras Genes H ras Genes H-ras Gene H-ras Oncogenes H-ras Oncogenes H ras Oncogenes H-ras Oncogene Ha-ras Genes Ha-ras Genes Gene, Ha-ras Genes, Ha-ras Ha ras Genes Ha-ras Gene K-ras Genes K-ras Genes K ras Genes K-ras Gene K-ras Oncogenes K-ras Oncogenes K ras Oncogenes K-ras Oncogene Ki-ras Genes Ki-ras Genes Gene, Ki-ras Genes, Ki-ras Ki ras Genes Ki-ras Gene Ki-ras Oncogenes Ki-ras Oncogenes Ki ras Oncogenes Ki-ras Oncogene ras Oncogene ras Oncogene ras Oncogenes v-H-ras Genes v-H-ras Genes v H ras Genes v-H-ras Gene

Below are MeSH descriptors whose meaning is more general than "Genes, ras".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Oncogenes [G05.360.340.024.340.375.500]
Proto-Oncogenes [G05.360.340.024.340.375.500.791]
Genes, ras [G05.360.340.024.340.375.500.791.550]

Below are MeSH descriptors whose meaning is related to "Genes, ras".

Below are MeSH descriptors whose meaning is more specific than "Genes, ras".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, ras" by people in this website by year, and whether "Genes, ras" was a major or minor topic of these publications.

Bar chart showing 80 publications over 25 distinct years, with a maximum of 6 publications in 1998 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	1	4	5
1998	4	2	6
1999	0	3	3
2000	1	3	4
2001	1	2	3
2002	2	1	3
2003	1	3	4
2004	2	1	3
2005	1	3	4
2006	1	5	6
2007	1	4	5
2008	3	0	3
2009	2	0	2
2010	1	1	2
2011	1	2	3
2012	1	4	5
2013	0	3	3
2014	1	2	3
2015	0	1	1
2016	0	1	1
2017	1	2	3
2018	1	1	2
2019	0	3	3
2022	0	1	1

Below are the most recent publications written about "Genes, ras" by people in Profiles.

Redding A, Aplin AE, Grabocka E. RAS-mediated tumor stress adaptation and the targeting opportunities it presents. Dis Model Mech. 2022 02 01; 15(2).

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McCallen LM, Ameduri RK, Denfield SW, Dodd DA, Everitt MD, Johnson JN, Lee TM, Lin AE, Lohr JL, May LJ, Pierpont ME, Stevenson DA, Chatfield KC. Cardiac transplantation in children with Noonan syndrome. Pediatr Transplant. 2019 09; 23(6):e13535.

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Pool C, Walter V, Bann D, Goldenberg D, Broach J, Hennessy M, Cottrill E, Washburn E, Williams N, Crist H, Imamura Y, Warrick JI. Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Virchows Arch. 2019 Mar; 474(3):341-351.

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Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, Sidoli S, Parris JLD, Affronti HC, Sivanand S, Egolf S, Sela Y, Trizzino M, Gardini A, Garcia BA, Snyder NW, Stanger BZ, Wellen KE. Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. Cancer Discov. 2019 03; 9(3):416-435.

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Seehawer M, Heinzmann F, D'Artista L, Harbig J, Roux PF, Hoenicke L, Dang H, Klotz S, Robinson L, Dor? G, Rozenblum N, Kang TW, Chawla R, Buch T, Vucur M, Roth M, Zuber J, Luedde T, Sipos B, Longerich T, Heikenw?lder M, Wang XW, Bischof O, Zender L. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. 2018 10; 562(7725):69-75.

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Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018 05 08; 9(1):1816.

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Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Fruth B, Meyerhardt JA, Schrag D, Greene C, O'Neil BH, Atkins JN, Berry S, Polite BN, O'Reilly EM, Goldberg RM, Hochster HS, Schilsky RL, Bertagnolli MM, El-Khoueiry AB, Watson P, Benson AB, Mulkerin DL, Mayer RJ, Blanke C. Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA. 2017 06 20; 317(23):2392-2401.

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Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED, D'Agostino RB, Petro RM, Blackstock W, Powell BL, Abraham E, Pasche B, Zhang W. Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. J Hematol Oncol. 2017 05 04; 10(1):100.

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Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 03 09; 2(5):e91225.

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Manara MC, Terracciano M, Mancarella C, Sciandra M, Guerzoni C, Pasello M, Grilli A, Zini N, Picci P, Colombo MP, Morrione A, Scotlandi K. CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget. 2016 Nov 29; 7(48):79925-79942.

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