Genes, ras

"Genes, ras" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Descriptor ID	D011905
MeSH Number(s)	G05.360.340.024.340.375.500.791.550
Concept/Terms	Genes, ras Genes, ras ras Genes ras Gene N-ras Genes N-ras Genes Genes, N-ras N ras Genes N-ras Gene N-ras Oncogenes N ras Oncogenes N-ras Oncogene v-H-ras Oncogenes v-H-ras Oncogenes v H ras Oncogenes v-H-ras Oncogene v-Ha-ras Genes v-Ha-ras Genes Gene, v-Ha-ras Genes, v-Ha-ras v Ha ras Genes v-Ha-ras Gene v-Ha-ras Oncogenes v-Ha-ras Oncogenes v Ha ras Oncogenes v-Ha-ras Oncogene v-K-ras Genes v-K-ras Genes v K ras Genes v-K-ras Gene v-K-ras Oncogenes v-K-ras Oncogenes v K ras Oncogenes v-K-ras Oncogene v-Ki-ras Genes v-Ki-ras Genes Gene, v-Ki-ras Genes, v-Ki-ras v Ki ras Genes v-Ki-ras Gene v-Ki-ras Oncogenes v-Ki-ras Oncogenes v Ki ras Oncogenes v-Ki-ras Oncogene c-H-ras Genes c-H-ras Genes c H ras Genes c-H-ras Gene c-H-ras Proto-Oncogenes c-H-ras Proto-Oncogenes c H ras Proto Oncogenes c-H-ras Proto-Oncogene c-Ha-ras Genes c-Ha-ras Genes c Ha ras Genes c-Ha-ras Gene Ha-ras Oncogenes Ha-ras Oncogenes Ha ras Oncogenes Ha-ras Oncogene c-Ha-ras Proto-Oncogenes c-Ha-ras Proto-Oncogenes c Ha ras Proto Oncogenes c-Ha-ras Proto-Oncogene c-K-ras Genes c-K-ras Genes c K ras Genes c-K-ras Gene c-K-ras Proto-Oncogenes c-K-ras Proto-Oncogenes c K ras Proto Oncogenes c-K-ras Proto-Oncogene c-Ki-ras Genes c-Ki-ras Genes c Ki ras Genes c-Ki-ras Gene c-Ki-ras Proto-Oncogenes c-Ki-ras Proto-Oncogenes c Ki ras Proto Oncogenes c-Ki-ras Proto-Oncogene c-N-ras Genes c-N-ras Genes c N ras Genes c-N-ras Gene c-N-ras Proto-Oncogenes c-N-ras Proto-Oncogenes c N ras Proto Oncogenes c-N-ras Proto-Oncogene H-ras Genes H-ras Genes H ras Genes H-ras Gene H-ras Oncogenes H-ras Oncogenes H ras Oncogenes H-ras Oncogene Ha-ras Genes Ha-ras Genes Gene, Ha-ras Genes, Ha-ras Ha ras Genes Ha-ras Gene K-ras Genes K-ras Genes K ras Genes K-ras Gene K-ras Oncogenes K-ras Oncogenes K ras Oncogenes K-ras Oncogene Ki-ras Genes Ki-ras Genes Gene, Ki-ras Genes, Ki-ras Ki ras Genes Ki-ras Gene Ki-ras Oncogenes Ki-ras Oncogenes Ki ras Oncogenes Ki-ras Oncogene ras Oncogene ras Oncogene ras Oncogenes v-H-ras Genes v-H-ras Genes v H ras Genes v-H-ras Gene

Below are MeSH descriptors whose meaning is more general than "Genes, ras".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Oncogenes [G05.360.340.024.340.375.500]
Proto-Oncogenes [G05.360.340.024.340.375.500.791]
Genes, ras [G05.360.340.024.340.375.500.791.550]

Below are MeSH descriptors whose meaning is related to "Genes, ras".

Below are MeSH descriptors whose meaning is more specific than "Genes, ras".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, ras" by people in this website by year, and whether "Genes, ras" was a major or minor topic of these publications.

Bar chart showing 49 publications over 20 distinct years, with a maximum of 6 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	3	3
1998	4	2	6
1999	0	2	2
2000	0	3	3
2001	0	2	2
2002	1	1	2
2003	0	3	3
2004	1	1	2
2005	0	1	1
2006	1	3	4
2007	1	3	4
2008	1	0	1
2009	2	0	2
2010	0	1	1
2011	0	1	1
2012	1	4	5
2013	0	3	3
2015	0	1	1
2017	1	1	2

Below are the most recent publications written about "Genes, ras" by people in Profiles.

Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Fruth B, Meyerhardt JA, Schrag D, Greene C, O'Neil BH, Atkins JN, Berry S, Polite BN, O'Reilly EM, Goldberg RM, Hochster HS, Schilsky RL, Bertagnolli MM, El-Khoueiry AB, Watson P, Benson AB, Mulkerin DL, Mayer RJ, Blanke C. Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA. 2017 06 20; 317(23):2392-2401.

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Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 03 09; 2(5):e91225.

View in: PubMed
Gripp KW, Sol-Church K, Smpokou P, Graham GE, Stevenson DA, Hanson H, Viskochil DH, Baker LC, Russo B, Gardner N, Stabley DL, Kolbe V, Rosenberger G. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences. Am J Med Genet A. 2015 Sep; 167A(9):2085-97.

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Jain N, Curran E, Iyengar NM, Diaz-Flores E, Kunnavakkam R, Popplewell L, Kirschbaum MH, Karrison T, Erba HP, Green M, Poire X, Koval G, Shannon K, Reddy PL, Joseph L, Atallah EL, Dy P, Thomas SP, Smith SE, Doyle LA, Stadler WM, Larson RA, Stock W, Odenike O. Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial. Clin Cancer Res. 2014 Jan 15; 20(2):490-8.

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Garrett CR, Bekaii-Saab TS, Ryan T, Fisher GA, Clive S, Kavan P, Shacham-Shmueli E, Buchbinder A, Goldberg RM. Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer. Cancer. 2013 Dec 15; 119(24):4223-30.

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Le K, Blomain ES, Rodeck U, Aplin AE. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul; 26(4):509-17.

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Ju X, Ertel A, Casimiro MC, Yu Z, Meng H, McCue PA, Walters R, Fortina P, Lisanti MP, Pestell RG. Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures. Cancer Res. 2013 Jan 15; 73(2):978-89.

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Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012 Nov 15; 72(22):5966-75.

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Sammon MR, Doyle D, Hopkins E, Sol-Church K, Stabley DL, McGready J, Schulze K, Alade Y, Hoover-Fong J, Gripp KW. Normative growth charts for individuals with Costello syndrome. Am J Med Genet A. 2012 Nov; 158A(11):2692-9.

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Smith C, Chang MY, Parker KH, Beury DW, DuHadaway JB, Flick HE, Boulden J, Sutanto-Ward E, Soler AP, Laury-Kleintop LD, Mandik-Nayak L, Metz R, Ostrand-Rosenberg S, Prendergast GC, Muller AJ. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov. 2012 Aug; 2(8):722-35.

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