"Genes, bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
| Descriptor ID |
D019254
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.150
|
| Concept/Terms |
Genes, bcl-2- Genes, bcl-2
- Genes, bcl 2
- bcl-2 Genes
- Gene, bcl-2
- bcl 2 Genes
- bcl-2 Gene
c-bcl-2 Genes- c-bcl-2 Genes
- Gene, c-bcl-2
- Genes, c-bcl-2
- c bcl 2 Genes
- c-bcl-2 Gene
- c-bcl-2 Proto-Oncogenes
- Proto-Oncogene, c-bcl-2
- Proto-Oncogenes, c-bcl-2
- c bcl 2 Proto Oncogenes
- c-bcl-2 Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, bcl-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, bcl-2".
This graph shows the total number of publications written about "Genes, bcl-2" by people in this website by year, and whether "Genes, bcl-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1999 | 1 | 1 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2007 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Genes, bcl-2" by people in Profiles.
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O'Neil BH, Funkhouser WK, Calvo BF, Meyers MO, Kim HJ, Goldberg RM, Bernard SA, Caskey L, Deal AM, Wright F, Baldwin AS, Tepper JE. Nuclear factor ?-light chain-enhancer of activated B cells is activated by radiotherapy and is prognostic for overall survival in patients with rectal cancer treated with preoperative fluorouracil-based chemoradiotheraphy. Int J Radiat Oncol Biol Phys. 2011 Jul 01; 80(3):705-11.
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Wei W, Howard PS, Kogan B, Macarak EJ. Altered extracellular matrix expression in the diverted fetal sheep bladder. J Urol. 2007 Sep; 178(3 Pt 1):1104-7.
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Tong WG, Ding XZ, Talamonti MS, Bell RH, Adrian TE. Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells. Anticancer Drugs. 2007 Jun; 18(5):535-41.
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Alabyev B, Manser T. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. J Immunol. 2002 Oct 01; 169(7):3819-24.
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Morris MJ, Tong WP, Cordon-Cardo C, Drobnjak M, Kelly WK, Slovin SF, Terry KL, Siedlecki K, Swanson P, Rafi M, DiPaola RS, Rosen N, Scher HI. Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer. Clin Cancer Res. 2002 Mar; 8(3):679-83.
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Eischen CM, Packham G, Nip J, Fee BE, Hiebert SW, Zambetti GP, Cleveland JL. Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene. 2001 Oct 25; 20(48):6983-93.
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Nakamura M, Raghupathi R, Merry DE, Scherbel U, Saatman KE, Mcintosh TK. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice. J Comp Neurol. 1999 Oct 04; 412(4):681-92.
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Hosler GA, Bash RO, Bai X, Jain V, Scheuermann RH. Development and validation of a quantitative polymerase chain reaction assay to evaluate minimal residual disease for T-cell acute lymphoblastic leukemia and follicular lymphoma. Am J Pathol. 1999 Apr; 154(4):1023-35.
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Skorski T, Bellacosa A, Nieborowska-Skorska M, Majewski M, Martinez R, Choi JK, Trotta R, Wlodarski P, Perrotti D, Chan TO, Wasik MA, Tsichlis PN, Calabretta B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 1997 Oct 15; 16(20):6151-61.
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Jena N, Mart?n-Seisdedos C, McCue P, Croce CM. BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res. 1997 Jan 10; 230(1):28-37.