"Dynactin Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-subunit protein of EUKARYOTIC CELLS. It functions in bidirectional intracellular transport of ORGANELLES and CYTOPLASMIC VESICLES by linking them to DYNEIN and KINESIN.
| Descriptor ID |
D000072159
|
| MeSH Number(s) |
D05.500.142 D12.776.220.600.450.150 D12.776.631.560.225
|
| Concept/Terms |
Dynactin Subunit 2- Dynactin Subunit 2
- Dynamitin Protein
- p50 Dynamitin
- Dynamitin, p50
- Dynactin-2
- Dynactin 2
Dynactin Subunit 1- Dynactin Subunit 1
- Dynein Activator Protein
- p150(Glued)
- 150 kDa Dynein-Associated Protein
- 150 kDa Dynein Associated Protein
- Dynein-Associated Protein, 150-kDa
- 150-kDa Dynein-Associated Protein
- Dynein Associated Protein, 150 kDa
- Dynactin
- Dynactin 1
|
Below are MeSH descriptors whose meaning is more general than "Dynactin Complex".
Below are MeSH descriptors whose meaning is more specific than "Dynactin Complex".
This graph shows the total number of publications written about "Dynactin Complex" by people in this website by year, and whether "Dynactin Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dynactin Complex" by people in Profiles.
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Alexander GM, Heiman-Patterson TD, Bearoff F, Sher RB, Hennessy L, Terek S, Caccavo N, Cox GA, Philip VM, Blankenhorn EA. Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease. PLoS One. 2022; 17(9):e0274615.
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Guo C, Williams JC, Polenova T. Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules. Biophys J. 2019 09 03; 117(5):938-949.
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Yan S, Guo C, Hou G, Zhang H, Lu X, Williams JC, Polenova T. Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14611-6.
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Yan S, Zhang H, Hou G, Ahmed S, Williams JC, Polenova T. Internal dynamics of dynactin CAP-Gly is regulated by microtubules and plus end tracking protein EB1. J Biol Chem. 2015 Jan 16; 290(3):1607-22.
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Yan S, Hou G, Schwieters CD, Ahmed S, Williams JC, Polenova T. Three-dimensional structure of CAP-gly domain of mammalian dynactin determined by magic angle spinning NMR spectroscopy: conformational plasticity and interactions with end-binding protein EB1. J Mol Biol. 2013 Nov 15; 425(22):4249-66.
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Siglin AE, Sun S, Moore JK, Tan S, Poenie M, Lear JD, Polenova T, Cooper JA, Williams JC. Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. PLoS One. 2013; 8(4):e59453.
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Ahmed S, Sun S, Siglin AE, Polenova T, Williams JC. Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain. Biochemistry. 2010 Jun 29; 49(25):5083-5.
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Sun S, Siglin A, Williams JC, Polenova T. Solid-state and solution NMR studies of the CAP-Gly domain of mammalian dynactin and its interaction with microtubules. J Am Chem Soc. 2009 Jul 29; 131(29):10113-26.
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Zhao Y, Gaidarov I, Keen JH. Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement. J Biol Chem. 2007 Jan 12; 282(2):1249-56.