Mediator Complex

"Mediator Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

Descriptor ID	D056892
MeSH Number(s)	D05.500.374 D12.644.360.024.309 D12.776.157.057.072 D12.776.476.024.388 D12.776.660.551
Concept/Terms	Mediator Complex Mediator Complex Mediator Transcription Complex Thyroid Hormone-Associated Protein Complex Thyroid Hormone-Associated Protein Complex Thyroid Hormone Associated Protein Complex TRAP (Thyroid Hormone Associated Protein) Complex TR-Associated Protein (TRAP) Complex Mediator-Like Complexes Mediator-Like Complexes Mediator Like Complexes Mediator-Like Complex Mediator Like Complex

Below are MeSH descriptors whose meaning is more general than "Mediator Complex".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Mediator Complex [D05.500.374]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Mediator Complex [D12.644.360.024.309]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Mediator Complex [D12.776.157.057.072]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Mediator Complex [D12.776.476.024.388]
Nuclear Proteins [D12.776.660]
Mediator Complex [D12.776.660.551]

Below are MeSH descriptors whose meaning is related to "Mediator Complex".

Below are MeSH descriptors whose meaning is more specific than "Mediator Complex".

publications

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This graph shows the total number of publications written about "Mediator Complex" by people in this website by year, and whether "Mediator Complex" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2016 and 2018 and 2021 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	1	0	1
2018	1	0	1
2021	0	1	1
2023	0	1	1

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