Codon, Nonsense

"Codon, Nonsense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Descriptor ID	D018389
MeSH Number(s)	D13.444.735.544.355.250.235 G05.360.335.355.250.235 G05.365.590.195
Concept/Terms	Codon, Nonsense Codon, Nonsense Premature Termination Codon Codon, Premature Termination Codons, Premature Termination Premature Termination Codons Termination Codon, Premature Termination Codons, Premature Premature Stop Codon Codon, Premature Stop Codons, Premature Stop Premature Stop Codons Stop Codon, Premature Stop Codons, Premature Nonsense Codon Codons, Nonsense Nonsense Codons Codon, Termination, Premature Mutation, Nonsense Mutation, Nonsense Mutations, Nonsense Nonsense Mutations Nonsense Mutation Ochre Nonsense Codon Ochre Nonsense Codon Codon, Ochre Nonsense Codons, Ochre Nonsense Nonsense Codon, Ochre Nonsense Codons, Ochre Ochre Nonsense Codons Ochre Nonsense Mutation Ochre Nonsense Mutation Mutation, Ochre Nonsense Mutations, Ochre Nonsense Nonsense Mutation, Ochre Nonsense Mutations, Ochre Ochre Nonsense Mutations Amber Nonsense Mutation Amber Nonsense Mutation Amber Nonsense Mutations Mutation, Amber Nonsense Mutations, Amber Nonsense Nonsense Mutation, Amber Nonsense Mutations, Amber Opal Nonsense Mutation Opal Nonsense Mutation Mutation, Opal Nonsense Mutations, Opal Nonsense Nonsense Mutation, Opal Nonsense Mutations, Opal Opal Nonsense Mutations Amber Nonsense Codon Amber Nonsense Codon Amber Nonsense Codons Codon, Amber Nonsense Codons, Amber Nonsense Nonsense Codons, Amber Nonsense Codon, Amber Codon, Unassigned Codon, Unassigned Codons, Unassigned Unassigned Codons Unassigned Codon Opal Nonsense Codon Opal Nonsense Codon Codon, Opal Nonsense Codons, Opal Nonsense Nonsense Codon, Opal Nonsense Codons, Opal Opal Nonsense Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Nonsense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Codon, Nonsense [D13.444.735.544.355.250.235]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Codon, Nonsense [G05.360.335.355.250.235]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Codon, Nonsense [G05.365.590.195]

Below are MeSH descriptors whose meaning is more specific than "Codon, Nonsense".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Nonsense" by people in this website by year, and whether "Codon, Nonsense" was a major or minor topic of these publications.

Bar chart showing 52 publications over 21 distinct years, with a maximum of 6 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	0	1	1
1999	0	1	1
2002	1	0	1
2003	2	2	4
2004	1	3	4
2005	1	0	1
2006	1	2	3
2007	1	2	3
2008	1	3	4
2009	1	0	1
2010	2	3	5
2011	1	2	3
2013	6	0	6
2014	2	2	4
2017	0	3	3
2018	1	0	1
2019	0	1	1
2020	0	1	1
2022	2	0	2
2023	0	2	2

Below are the most recent publications written about "Codon, Nonsense" by people in Profiles.

Paredes DI, Bello NR, Capasso JE, Procopio R, Levin AV. Mutations in AGBL5 associated with Retinitis pigmentosa. Ophthalmic Genet. 2024 06; 45(3):275-280.

View in: PubMed
Rayinda T, McSweeney SM, Lalagianni N, Liu L, Guy A, Fenton D, Stefanato CM, Dand N, McGrath JA, Tziotzios C. Familial hypotrichosis simplex of the scalp associated with a novel heterozygous nonsense variant in CDSN. Clin Exp Dermatol. 2023 04 27; 48(5):579-583.

View in: PubMed
Sheriff A, Guri I, Zebrowska P, Llopis-Hernandez V, Brooks IR, Tekkela S, Subramaniam K, Gebrezgabher R, Naso G, Petrova A, Balon K, Onoufriadis A, Kujawa D, Kotulska M, Newby G, Laczmanski L, Liu DR, McGrath JA, Jack?w J. ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation. Sci Rep. 2022 11 16; 12(1):19643.

View in: PubMed
Makay P, Mubungu G, Mupuala A, Bluske K, Brown C, Schmidt SA, Ngole M, Fuanani P, Perry DL, Lukusa P, Devriendt K, Taft RJ, Lumaka A. PERCHING syndrome: Clinical presentation in the first African patient confirmed by clinical whole genome sequencing. Am J Med Genet A. 2022 09; 188(9):2825-2831.

View in: PubMed
O'Sullivan S, Ozoemena L, Liu L, McGrath JA, Mellerio JE, Martinez AE. PLACK syndrome: the penny dropped. Clin Exp Dermatol. 2020 Dec; 45(8):1091-1092.

View in: PubMed
Onoufriadis A, Ahmed N, Bessar H, Guy A, Liu L, Marantzidis A, Kesidou E, Papanikolaou M, Simpson MA, Mellerio JE, Lee JYW, McGrath JA. Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis. J Invest Dermatol. 2020 06; 140(6):1285-1288.

View in: PubMed
Lincoln V, Cogan J, Hou Y, Hirsch M, Hao M, Alexeev V, De Luca M, De Rosa L, Bauer JW, Woodley DT, Chen M. Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6536-E6545.

View in: PubMed
Ohguchi Y, Nomura T, Suzuki S, Takeda M, Miyauchi T, Mizuno O, Shinkuma S, Fujita Y, Nemoto O, Ono K, McLean WHI, Shimizu H. Gentamicin-Induced Readthrough and Nonsense-Mediated mRNA Decay of SERPINB7 Nonsense Mutant Transcripts. J Invest Dermatol. 2018 04; 138(4):836-843.

View in: PubMed
Straussberg R, Onoufriadis A, Konen O, Zouabi Y, Cohen L, Lee JYW, Hsu CK, Simpson MA, McGrath JA. Novel homozygous missense mutation in NT5C2 underlying hereditary spastic paraplegia SPG45. Am J Med Genet A. 2017 Nov; 173(11):3109-3113.

View in: PubMed
Atanasova VS, Jiang Q, Prisco M, Gruber C, Pi??n Hofbauer J, Chen M, Has C, Bruckner-Tuderman L, McGrath JA, Uitto J, South AP. Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. J Invest Dermatol. 2017 09; 137(9):1842-1849.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement