T-Box Domain Proteins

"T-Box Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.

Descriptor ID	D020825
MeSH Number(s)	D12.776.260.725 D12.776.930.850
Concept/Terms	T-Box Domain Proteins T-Box Domain Proteins Proteins, T-Box Domain T Box Domain Proteins

Below are MeSH descriptors whose meaning is more general than "T-Box Domain Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
T-Box Domain Proteins [D12.776.260.725]
Transcription Factors [D12.776.930]
T-Box Domain Proteins [D12.776.930.850]

Below are MeSH descriptors whose meaning is related to "T-Box Domain Proteins".

Below are MeSH descriptors whose meaning is more specific than "T-Box Domain Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of these publications.

Bar chart showing 23 publications over 14 distinct years, with a maximum of 5 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2006	0	2	2
2007	1	0	1
2008	0	1	1
2009	0	1	1
2010	0	1	1
2012	0	1	1
2014	1	0	1
2015	3	2	5
2016	0	2	2
2017	0	2	2
2018	0	1	1
2020	2	0	2
2024	2	0	2

Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles.

Raygada M, John L, Liu A, Schultz J, Thomas BJ, Bernstein D, Miettinen M, Raffeld M, Xi L, Tyagi M, Aldape K, Glod J, Reilly KM, Widemann BC, Wedekind MF. Germline findings in cancer predisposing genes from a small cohort of chordoma patients. J Cancer Res Clin Oncol. 2024 May 03; 150(5):227.

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Ramirez A, Vyzas CA, Zhao H, Eng K, Degenhardt K, Astrof S. Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease. Circ Res. 2024 May 10; 134(10):e112-e132.

View in: PubMed
Rasouli J, Casella G, Yoshimura S, Zhang W, Xiao D, Garifallou J, Gonzalez MV, Wiedeman A, Kus A, Mari ER, Fortina P, Hakonarson H, Long SA, Zhang GX, Ciric B, Rostami A. A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation. Sci Immunol. 2020 Oct 23; 5(52).

View in: PubMed
Thome R, Boehm A, Ishikawa LLW, Casella G, Munhoz J, Ciric B, Zhang GX, Rostami A. Chloroquine reduces Th17 cell differentiation by stimulating T-bet expression in T cells. Cell Mol Immunol. 2021 03; 18(3):779-780.

View in: PubMed
Seehawer M, Heinzmann F, D'Artista L, Harbig J, Roux PF, Hoenicke L, Dang H, Klotz S, Robinson L, Dor? G, Rozenblum N, Kang TW, Chawla R, Buch T, Vucur M, Roth M, Zuber J, Luedde T, Sipos B, Longerich T, Heikenw?lder M, Wang XW, Bischof O, Zender L. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. 2018 10; 562(7725):69-75.

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Bongiorno EK, Garcia SA, Sauma S, Hooper DC. Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors. J Immunol. 2017 06 01; 198(11):4513-4523.

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Yeung J, Goldowitz D. Wls expression in the rhombic lip orchestrates the embryonic development of the mouse cerebellum. Neuroscience. 2017 06 23; 354:30-42.

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Yeung J, Ha TJ, Swanson DJ, Goldowitz D. A Novel and Multivalent Role of Pax6 in Cerebellar Development. J Neurosci. 2016 08 31; 36(35):9057-69.

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Boxman J, Sagy N, Achanta S, Vadigepalli R, Nachman I. Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation. Sci Rep. 2016 08 17; 6:31623.

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Snyder CM. Front-Line Memory T Cells Think Outside the T-box? Mostly. Immunity. 2015 Dec 15; 43(6):1030-2.

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