NFATC Transcription Factors

"NFATC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

Descriptor ID	D050778
MeSH Number(s)	D12.776.930.608
Concept/Terms	NFATC Transcription Factors NFATC Transcription Factors Transcription Factors, NFATC Transcription Factor NF-AT NF-AT, Transcription Factor Transcription Factor NF AT Nuclear Factor of Activated T-Cells, Cytoplasmic Nuclear Factor of Activated T Cells, Cytoplasmic NFAT Proteins NFATC Proteins Nuclear Factors of Activated T-Cells Nuclear Factors of Activated T Cells NF-AT Proteins NF AT Proteins NFAT Transcription Factor 4 NFAT Transcription Factor 4 NFATC3 Transcription Factor Factor, NFATC3 Transcription Transcription Factor, NFATC3 NFATx Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein NF-AT4 Protein NF AT4 Protein NFAT4 Protein NFATC3 Protein NFAT Transcription Factor 2 NFAT Transcription Factor 2 NFAT-2 Protein NFAT 2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein NFATC1 Protein NFATC1 Transcription Factor Factor, NFATC1 Transcription Transcription Factor, NFATC1 NF-ATc1 Protein NF ATc1 Protein NFAT2 Protein NFAT Transcription Factor 3 NFAT Transcription Factor 3 NFATC4 Transcription Factor Transcription Factor, NFATC4 NFAT3 Protein NFATC4 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein NF-AT3 Protein NF AT3 Protein NFAT Transcription Factor 5 NFAT Transcription Factor 5 Nuclear Factor of Activated T-Cells 5 Protein Nuclear Factor of Activated T Cells 5 Protein OREBP Protein Osmotic Response Element Binding Protein NFATL1 Protein Tonicity-Responsive Enhancer-Binding Protein Tonicity Responsive Enhancer Binding Protein NFAT5 Protein NFATz Protein TonEBP Protein NFAT Transcription Factor 1 NFAT Transcription Factor 1 NFATC2 Transcription Factor Factor, NFATC2 Transcription Transcription Factor, NFATC2 NFAT1 Protein NFATC2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein NFAT-1 Protein NFAT 1 Protein

Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
NFATC Transcription Factors [D12.776.930.608]

Below are MeSH descriptors whose meaning is related to "NFATC Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NFATC Transcription Factors" by people in this website by year, and whether "NFATC Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 10 publications over 6 distinct years, with a maximum of 3 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2006	1	2	3
2010	0	1	1
2012	1	1	2
2014	1	1	2
2015	1	0	1

Below are the most recent publications written about "NFATC Transcription Factors" by people in Profiles.

Tomkowicz B, Walsh E, Cotty A, Verona R, Sabins N, Kaplan F, Santulli-Marotto S, Chin CN, Mooney J, Lingham RB, Naso M, McCabe T. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. PLoS One. 2015; 10(10):e0140694.

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Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res. 2014 Dec 05; 115(12):976-85.

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Lodhi N, Kossenkov AV, Tulin AV. Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark. Nucleic Acids Res. 2014 Jun; 42(11):7028-38.

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Goyal A, Poluzzi C, Willis CD, Smythies J, Shellard A, Neill T, Iozzo RV. Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1a and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation. J Biol Chem. 2012 Dec 21; 287(52):43543-56.

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Kinoshita SM, Krutzik PO, Nolan GP. COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One. 2012; 7(7):e41725.

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Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2011 Mar; 50(3):460-70.

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Knickelbein JE, de Souza AJ, Tosti R, Narayan P, Kane LP. Cutting edge: inhibition of T cell activation by TIM-2. J Immunol. 2006 Oct 15; 177(8):4966-70.

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Tsai TT, Danielson KG, Guttapalli A, Oguz E, Albert TJ, Shapiro IM, Risbud MV. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. J Biol Chem. 2006 Sep 01; 281(35):25416-24.

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Narayan P, Holt B, Tosti R, Kane LP. CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol. 2006 Mar; 26(6):2327-36.

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Bassuk AG, Anandappa RT, Leiden JM. Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. J Virol. 1997 May; 71(5):3563-73.

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