eIF-2 Kinase

"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Descriptor ID	D019892
MeSH Number(s)	D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
Concept/Terms	eIF-2 Kinase eIF-2 Kinase Kinase, eIF-2 eIF 2 Kinase DAI Protein Kinase Kinase, DAI Protein Protein Kinase, DAI Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) dsRNA-Activated Inhibitor Inhibitor, dsRNA-Activated dsRNA Activated Inhibitor DSRNA-Dep Protein Kinase DSRNA Dep Protein Kinase Kinase, DSRNA-Dep Protein Protein Kinase, DSRNA-Dep eIF-2alpha Kinase Kinase, eIF-2alpha eIF 2alpha Kinase eRF, eIF-2 Recycling Factor eRF, eIF 2 Recycling Factor Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Repressor Controlled Repressor, Heme Repressor, Heme Controlled Heme-Controlled Inhibitor Heme Controlled Inhibitor Inhibitor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Regulated eIF 2alpha Kinase Kinase, Heme-Regulated eIF-2alpha eIF-2alpha Kinase, Heme-Regulated Hemin Controlled Repressor Controlled Repressor, Hemin Repressor, Hemin Controlled p68 Kinase Kinase, p68 Self-Phosphorylating Protein Kinase Kinase, Self-Phosphorylating Protein Protein Kinase, Self-Phosphorylating Self Phosphorylating Protein Kinase TIK Kinase Kinase, TIK P68 Protein Kinase Kinase, P68 Protein Protein Kinase, P68 RNA-Dependent Protein Kinase Kinase, RNA-Dependent Protein Protein Kinase, RNA-Dependent RNA Dependent Protein Kinase p65 Kinase Kinase, p65 Protein Kinase PKR Kinase PKR, Protein PKR, Protein Kinase Protein Kinase, RNA Activated Heme-Controlled Translational Repressor Heme Controlled Translational Repressor Repressor, Heme-Controlled Translational Translational Repressor, Heme-Controlled Hemin-Controlled Translational Repressor Hemin Controlled Translational Repressor Repressor, Hemin-Controlled Translational Translational Repressor, Hemin-Controlled

Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
eIF-2 Kinase [D12.644.360.275]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
eIF-2 Kinase [D12.776.476.275]

Below are MeSH descriptors whose meaning is related to "eIF-2 Kinase".

Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2017	1	1	2
2019	1	0	1
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.

Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).

View in: PubMed
Kapoor A, Chen CG, Iozzo RV. Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells. J Biol Chem. 2020 05 08; 295(19):6344-6356.

View in: PubMed
Piazzi M, Bavelloni A, Greco S, Focaccia E, Orsini A, Benini S, Gambarotti M, Faenza I, Blalock WL. Expression of the double-stranded RNA-dependent kinase PKR influences osteosarcoma attachment independent growth, migration, and invasion. J Cell Physiol. 2020 02; 235(2):1103-1119.

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Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 01; 20(1):104-115.

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Shah D, Romero F, Guo Z, Sun J, Li J, Kallen CB, Naik UP, Summer R. Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 08; 57(2):204-215.

View in: PubMed
Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR. Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. J Virol. 2006 Feb; 80(3):1110-20.

View in: PubMed

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