MAP Kinase Kinase Kinase 5
"MAP Kinase Kinase Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE 4; and MAP KINASE KINASE 6.
| Descriptor ID |
D048848
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.500 D12.644.360.400.500 D12.776.476.400.500
|
| Concept/Terms |
MAP Kinase Kinase Kinase 5- MAP Kinase Kinase Kinase 5
- Apoptosis Signal-Regulating Kinase 1
- Apoptosis Signal Regulating Kinase 1
- MAPK Kinase Kinase 5
- MAP3K5 Protein Kinase
- Protein Kinase, MAP3K5
- Mitogen-Activated Kinase Kinase Kinase Kinase 5
- Mitogen Activated Kinase Kinase Kinase Kinase 5
- ASK1 Protein Kinase
- Protein Kinase, ASK1
- MAPKKK5
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 5".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 5".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 5" by people in this website by year, and whether "MAP Kinase Kinase Kinase 5" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "MAP Kinase Kinase Kinase 5" by people in Profiles.
-
Kostyak JC, McKenzie SE, Naik UP. The Function of ASK1 in Sepsis and Stress-Induced Disorders. Int J Mol Sci. 2023 Dec 22; 25(1).
-
Giri H, Srivastava AK, Naik UP. Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability. Vascul Pharmacol. 2022 08; 145:107088.
-
Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP. Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock. J Thromb Haemost. 2020 11; 18(11):3013-3028.
-
Patel P, Naik MU, Golla K, Shaik NF, Naik UP. Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets. Biochem J. 2019 10 15; 476(19):2835-2850.
-
Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P. Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease. Clin Sci (Lond). 2018 07 31; 132(14):1615-1627.
-
Zhang QS, Kurpad DS, Mahoney MG, Steinbeck MJ, Freeman TA. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration. PLoS One. 2017; 12(10):e0185803.
-
Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ. CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. Sci Rep. 2017 09 22; 7(1):12178.
-
Naik MU, Patel P, Derstine R, Turaga R, Chen X, Golla K, Neeves KB, Ichijo H, Naik UP. Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation. Blood. 2017 03 02; 129(9):1197-1209.
-
Zhang QS, Eaton GJ, Diallo C, Freeman TA. Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis. J Cell Physiol. 2016 04; 231(4):944-53.
-
Eaton GJ, Zhang QS, Diallo C, Matsuzawa A, Ichijo H, Steinbeck MJ, Freeman TA. Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival. Cell Death Dis. 2014 Nov 13; 5:e1522.