Pituitary Adenylate Cyclase-Activating Polypeptide

"Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.

Descriptor ID	D051219
MeSH Number(s)	D12.644.276.860.887 D12.644.400.625 D12.776.467.860.887 D12.776.631.600.887 D12.776.631.650.625 D23.529.850.887
Concept/Terms	Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide PACAP Pituitary Adenylate Cyclase Activating Polypeptide Pituitary Adenylate Cyclase Activating Polypeptide 38 Pituitary Adenylate Cyclase Activating Polypeptide 38 PACAP-38 PACAP38 Pituitary Adenylate Cyclase Activating Polypeptide 27 Pituitary Adenylate Cyclase Activating Polypeptide 27 PACAP-27 PACAP27

Below are MeSH descriptors whose meaning is more general than "Pituitary Adenylate Cyclase-Activating Polypeptide".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Nerve Growth Factors [D12.644.276.860]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.644.276.860.887]
Neuropeptides [D12.644.400]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.644.400.625]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Nerve Growth Factors [D12.776.467.860]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.467.860.887]
Nerve Tissue Proteins [D12.776.631]
Nerve Growth Factors [D12.776.631.600]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.631.600.887]
Neuropeptides [D12.776.631.650]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.631.650.625]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Nerve Growth Factors [D23.529.850]
Pituitary Adenylate Cyclase-Activating Polypeptide [D23.529.850.887]

Below are MeSH descriptors whose meaning is related to "Pituitary Adenylate Cyclase-Activating Polypeptide".

Below are MeSH descriptors whose meaning is more specific than "Pituitary Adenylate Cyclase-Activating Polypeptide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in this website by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2007	1	0	1
2009	1	0	1
2013	1	0	1
2016	1	0	1
2021	0	2	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles.

Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Amin FM, Burstein R, Ashina H. Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial. Brain. 2024 04 04; 147(4):1312-1320.

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Nerli R, Kalloli M, Rangrez S, Ghagane SC, Vinchurkar K, Chandra S, Thakur ML. Diagnosis of Oral Cancers by Targeting VPAC Receptors: Preliminary Report. Asian Pac J Cancer Prev. 2023 05 01; 24(5):1711-1715.

View in: PubMed
Thakur ML, Tripathi SK, Gomella LG, Salmanoglu E, Kim S, Kelly WK, Keith SW, Intenzo C, McCue P, Hoffman-Censits J, Trabulsi EJ. Imaging urothelial bladder cancer: A VPAC PET targeted approach. Can J Urol. 2021 04; 28(2):10596-10602.

View in: PubMed
Yan BM, Gibson Depoy EM, Ahmad A, Nahas SJ. Biomarkers in Migraine. Neurol India. 2021 Mar-Apr; 69(Supplement):S17-S24.

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Kumar P, Tripathi SK, Chen CP, Mehta N, Paudyal B, Wickstrom E, Thakur ML. Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. Cancer Biother Radiopharm. 2016 Feb; 31(1):29-36.

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Thakur ML, Zhang K, Berger A, Cavanaugh B, Kim S, Channappa C, Frangos AJ, Wickstrom E, Intenzo CM. VPAC1 receptors for imaging breast cancer: a feasibility study. J Nucl Med. 2013 Jul; 54(7):1019-25.

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Thakur ML, Devadhas D, Zhang K, Pestell RG, Wang C, McCue P, Wickstrom E. Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products. J Nucl Med. 2010 Jan; 51(1):106-11.

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Zhang K, Aruva MR, Shanthly N, Cardi CA, Patel CA, Rattan S, Cesarone G, Wickstrom E, Thakur ML. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation. Regul Pept. 2007 Dec 04; 144(1-3):91-100.

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Ohsawa M, Brailoiu GC, Shiraki M, Dun NJ, Paul K, Tseng LF. Modulation of nociceptive transmission by pituitary adenylate cyclase activating polypeptide in the spinal cord of the mouse. Pain. 2002 Nov; 100(1-2):27-34.

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