Tissue Plasminogen Activator

"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Descriptor ID	D010959
MeSH Number(s)	D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
Concept/Terms	Tissue Plasminogen Activator Tissue Plasminogen Activator Plasminogen Activator, Tissue Tissue Activator D-44 Tissue Activator D 44 Tisokinase Tissue-Type Plasminogen Activator Tissue Type Plasminogen Activator TTPA T-Plasminogen Activator T Plasminogen Activator Alteplase Plasminogen Activator, Tissue-Type Plasminogen Activator, Tissue Type Activase Activase Actilyse Actilyse Lysatec rt-PA Lysatec rt PA Lysatec rtPA

Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Tissue Plasminogen Activator [D08.811.277.656.959.350.875]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
Plasminogen Activators [D12.776.124.125.662]
Tissue Plasminogen Activator [D12.776.124.125.662.768]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
Tissue Plasminogen Activator [D23.119.970]

Below are MeSH descriptors whose meaning is related to "Tissue Plasminogen Activator".

Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.

Bar chart showing 45 publications over 23 distinct years, with a maximum of 5 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	0	1	1
2001	2	0	2
2002	1	0	1
2003	1	0	1
2004	2	0	2
2006	1	0	1
2007	1	2	3
2008	2	1	3
2009	3	1	4
2010	1	0	1
2011	0	1	1
2012	0	1	1
2013	2	0	2
2014	1	0	1
2015	2	0	2
2016	1	0	1
2017	1	0	1
2018	1	1	2
2019	3	2	5
2020	2	1	3
2021	2	0	2
2022	1	3	4

Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.

Isaac E, Saherwal AA, Alam S. Systemic thrombolysis for acute central retinal artery occlusion in sickle cell disease: Case report. J Natl Med Assoc. 2022 Dec; 114(6):589-592.

View in: PubMed
Eskin B. In ischemic stroke, IV alteplase within 3 h of onset improves functional outcome vs. control. Ann Intern Med. 2022 09; 175(9):JC107.

View in: PubMed
Eskin B. In acute ischemic stroke, EVT alone vs. IV alteplase plus EVT did not differ for functional outcome at 90 d. Ann Intern Med. 2022 04; 175(4):JC42.

View in: PubMed
Kam W, Holmes DN, Hernandez AF, Saver JL, Fonarow GC, Smith EE, Bhatt DL, Schwamm LH, Reeves MJ, Matsouaka RA, Khan YM, Unverdorben M, Birmingham MC, Lyden PD, Asimos AW, Altschul D, Schoonover TL, Jumaa MA, Nomura JT, Suri MFK, Moore SA, Lafranchise EF, Olson D, Peterson ED, Xian Y. Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase. JAMA. 2022 02 22; 327(8):760-771.

View in: PubMed
Barbour J, Hushen P, Newman GC, Vidal J. Impact of an emergency medicine pharmacist on door to needle alteplase time and patient outcomes in acute ischemic stroke. Am J Emerg Med. 2022 Jan; 51:358-362.

View in: PubMed
Graif A, Grilli CJ, Scott AL, Patel KD, Zimmermann TJ, Wimmer NJ, Kimbiris G, Leung DA. Temporal Analysis of Tachycardia During Catheter Directed Thrombolysis for Acute Pulmonary Embolism. Vasc Endovascular Surg. 2021 Oct; 55(7):689-695.

View in: PubMed
Graif A, Patel KD, Wimmer NJ, Kimbiris G, Grilli CJ, Leung DA. Evaluation of the Benefit of Extended Catheter-Directed Thrombolysis with Serial Angiography for Acute Pulmonary Embolism. J Vasc Interv Radiol. 2021 01; 32(1):70-79.

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Matsunaga DR, Su D, Sioufi K, Obeid A, Wibbelsman T, Ho AC, Regillo CD. The Timing of Large Submacular Hemorrhage Secondary to Age-Related Macular Degeneration Relative to Anti-VEGF Therapy. Ophthalmol Retina. 2021 04; 5(4):342-347.

View in: PubMed
Graif A, Grilli CJ, Kimbiris G, Paik HH, Leung DA. Evaluation of Fibrinogen Levels during Catheter-Directed Thrombolysis for Acute Pulmonary Embolism. J Vasc Interv Radiol. 2020 08; 31(8):1281-1289.

View in: PubMed
Jung S, Rosini JM, Nomura JT, Caplan RJ, Raser-Schramm J. Even Faster Door-to-Alteplase Times and Associated Outcomes in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019 Dec; 28(12):104329.

View in: PubMed

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