"NLR Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
| Descriptor ID |
D000070576
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| MeSH Number(s) |
D12.644.360.539
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| Concept/Terms |
NLR Proteins- NLR Proteins
- Proteins, NLR
- NLR Protein
- Protein, NLR
- NOD-like Receptors
- NOD like Receptors
- Receptors, NOD-like
- Nucleotide-binding Domain Leucine-rich Repeat Proteins
- Nucleotide binding Domain Leucine rich Repeat Proteins
|
Below are MeSH descriptors whose meaning is more general than "NLR Proteins".
Below are MeSH descriptors whose meaning is more specific than "NLR Proteins".
This graph shows the total number of publications written about "NLR Proteins" by people in this website by year, and whether "NLR Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "NLR Proteins" by people in Profiles.
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Verma RN, Malik MZ, Subbarao N, Singh GP, Sinha DN. Entamoeba histolytica HM-1: IMSS gene expression profiling identifies key hub genes, potential biomarkers, and pathways in Amoebiasis infection: a systematic network meta-analysis. Biosci Rep. 2022 10 28; 42(10).
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Mantegazza AR, Wynosky-Dolfi MA, Casson CN, Lefkovith AJ, Shin S, Brodsky IE, Marks MS. Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity. PLoS Pathog. 2017 12; 13(12):e1006785.
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Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, N??ez G, Hardy RR. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. J Exp Med. 2017 Oct 02; 214(10):3067-3083.
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Zhong FL, Mama? O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szever?nyi I, Takeichi T, Balaji R, Lau A, Tye H, Roy K, Bonnard C, Ahl PJ, Jones LA, Baker PJ, Lacina L, Otsuka A, Fournie PR, Malecaze F, Lane EB, Akiyama M, Kabashima K, Connolly JE, Masters SL, Soler VJ, Omar SS, McGrath JA, Nedelcu R, Gribaa M, Denguezli M, Saad A, Hiller S, Reversade B. Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation. Cell. 2016 Sep 22; 167(1):187-202.e17.