Syk Kinase

"Syk Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.

Descriptor ID	D000072377
MeSH Number(s)	D08.811.913.696.620.682.725.650 D12.644.360.900 D12.776.476.913
Concept/Terms	Syk Kinase Syk Kinase Kinase, Syk SYK Tyrosine Kinase Kinase, SYK Tyrosine Tyrosine Kinase, SYK Spleen Tyrosine Kinase Kinase, Spleen Tyrosine Tyrosine Kinase, Spleen

Below are MeSH descriptors whose meaning is more general than "Syk Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Syk Kinase [D08.811.913.696.620.682.725.650]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Syk Kinase [D12.644.360.900]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Syk Kinase [D12.776.476.913]

Below are MeSH descriptors whose meaning is related to "Syk Kinase".

Below are MeSH descriptors whose meaning is more specific than "Syk Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Syk Kinase" by people in this website by year, and whether "Syk Kinase" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 4 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	0	1	1
2002	0	1	1
2004	0	1	1
2007	0	1	1
2010	0	2	2
2011	0	1	1
2013	0	1	1
2015	0	1	1
2016	2	2	4
2017	1	1	2
2022	1	0	1
2023	1	0	1

Below are the most recent publications written about "Syk Kinase" by people in Profiles.

Dangelmaier CA, Patchin M, Vajipayajula DN, Vari HR, Singh PK, Wright MN, Kostyak JC, Tsygankov AY, Kunapuli SP. Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets. J Biol Chem. 2023 07; 299(7):104865.

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Kostyak JC, Mauri B, Dangelmaier C, Vari HR, Patel A, Wright M, Reddy H, Tsygankov AY, Kunapuli SP. Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets. J Biol Chem. 2022 08; 298(8):102189.

View in: PubMed
Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 09; 18(6).

View in: PubMed
Moyo TK, Wilson CS, Moore DJ, Eischen CM. Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition. Oncogene. 2017 08 10; 36(32):4653-4661.

View in: PubMed
Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (Fc?RIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice. Arterioscler Thromb Vasc Biol. 2016 Dec; 36(12):2315-2323.

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Reppschl?ger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016 Oct 21; 291(43):22427-22441.

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McKenzie SE. Syk Inhibition in Ischemic Stroke. Arterioscler Thromb Vasc Biol. 2016 06; 36(6):1054-5.

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Buitrago L, Manne BK, Andre P, McKenzie S, Kunapuli S. Identification of novel Syk-independent functional roles of Fc?RIIa in platelet outside-in signaling using transgenic mice expressing human Fc?RIIa. Platelets. 2016 Jul; 27(5):488-90.

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Vu HL, Rosenbaum S, Purwin TJ, Davies MA, Aplin AE. RAC1 P29S regulates PD-L1 expression in melanoma. Pigment Cell Melanoma Res. 2015 Sep; 28(5):590-8.

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Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013 Oct 04; 288(40):29160-9.

View in: PubMed

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