Rho Guanine Nucleotide Exchange Factors
"Rho Guanine Nucleotide Exchange Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
| Descriptor ID |
D064067
|
| MeSH Number(s) |
D12.644.360.325.300.099 D12.776.476.325.300.099
|
| Concept/Terms |
Rho Guanine Nucleotide Exchange Factor 7- Rho Guanine Nucleotide Exchange Factor 7
- PAK-Interacting Exchange Factor beta
- PAK Interacting Exchange Factor beta
- Cool-1 Protein
- Cool 1 Protein
- Protein, Cool-1
- beta PIX Protein
- PIX Protein, beta
- Protein, beta PIX
- betaPIX Protein
- Protein, betaPIX
|
Below are MeSH descriptors whose meaning is more general than "Rho Guanine Nucleotide Exchange Factors".
Below are MeSH descriptors whose meaning is more specific than "Rho Guanine Nucleotide Exchange Factors".
This graph shows the total number of publications written about "Rho Guanine Nucleotide Exchange Factors" by people in this website by year, and whether "Rho Guanine Nucleotide Exchange Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Rho Guanine Nucleotide Exchange Factors" by people in Profiles.
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Chahdi A, Raufman JP. The Cdc42/Rac nucleotide exchange factor protein ß1Pix (Pak-interacting exchange factor) modulates ß-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of ß1PIX with ß-catenin. J Biol Chem. 2013 Nov 22; 288(47):34019-29.
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Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010 May; 21(5):833-43.
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Chahdi A, Sorokin A. The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1330-5.
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Chahdi A, Sorokin A. Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. Cell Signal. 2010 Feb; 22(2):325-9.
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Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009 Jan 01; 113(1):244-53.
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Chahdi A, Sorokin A. Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell. 2008 Jun; 19(6):2609-19.
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Chahdi A, Sorokin A. Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol. 2008 Mar; 28(5):1679-87.
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Chahdi A, Sorokin A. Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. Exp Biol Med (Maywood). 2006 Jun; 231(6):761-5.
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Chahdi A, Miller B, Sorokin A. Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem. 2005 Jan 7; 280(1):578-84.
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Chahdi A, Sorokin A, Dunn MJ, Landry Y. The Rac/Cdc42 guanine nucleotide exchange factor beta1Pix enhances mastoparan-activated Gi-dependent pathway in mast cells. Biochem Biophys Res Commun. 2004 Apr 30; 317(2):384-9.