Genes, myc

"Genes, myc" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.

Descriptor ID	D016259
MeSH Number(s)	G05.360.340.024.340.375.500.791.420
Concept/Terms	Genes, myc Genes, myc myc Genes Gene, myc myc Gene c-myc Genes c-myc Genes Gene, c-myc Genes, c-myc c myc Genes c-myc Gene c-myc Proto-Oncogenes c-myc Proto-Oncogenes Proto-Oncogene, c-myc Proto-Oncogenes, c-myc c myc Proto Oncogenes c-myc Proto-Oncogene v-myc Genes v-myc Genes Gene, v-myc Genes, v-myc v myc Genes v-myc Gene L-myc Proto-Oncogenes L-myc Proto-Oncogenes L myc Proto Oncogenes L-myc Proto-Oncogene Proto-Oncogene, L-myc Proto-Oncogenes, L-myc myc Oncogene myc Oncogene Oncogene, myc Oncogenes, myc myc Oncogenes N-myc Genes N-myc Genes Gene, N-myc Genes, N-myc N myc Genes N-myc Gene N-myc Proto-Oncogenes N-myc Proto-Oncogenes N myc Proto Oncogenes N-myc Proto-Oncogene Proto-Oncogene, N-myc Proto-Oncogenes, N-myc v-myc Oncogenes v-myc Oncogenes Oncogene, v-myc Oncogenes, v-myc v myc Oncogenes v-myc Oncogene L-myc Genes L-myc Genes Gene, L-myc Genes, L-myc L myc Genes L-myc Gene

Below are MeSH descriptors whose meaning is more general than "Genes, myc".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Oncogenes [G05.360.340.024.340.375.500]
Proto-Oncogenes [G05.360.340.024.340.375.500.791]
Genes, myc [G05.360.340.024.340.375.500.791.420]

Below are MeSH descriptors whose meaning is related to "Genes, myc".

Below are MeSH descriptors whose meaning is more specific than "Genes, myc".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, myc" by people in this website by year, and whether "Genes, myc" was a major or minor topic of these publications.

Bar chart showing 24 publications over 13 distinct years, with a maximum of 4 publications in 2003 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2001	1	0	1
2002	1	0	1
2003	2	2	4
2004	2	1	3
2006	0	1	1
2007	1	3	4
2009	1	1	2
2010	1	1	2
2011	1	1	2
2014	0	1	1
2017	0	1	1
2018	1	0	1

Below are the most recent publications written about "Genes, myc" by people in Profiles.

Srutova K, Curik N, Burda P, Savvulidi F, Silvestri G, Trotta R, Klamova H, Pecherkova P, Sovova Z, Koblihova J, Stopka T, Perrotti D, Polakova KM. BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia. Haematologica. 2018 12; 103(12):2016-2025.

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Barrett MT, Deiotte R, Lenkiewicz E, Malasi S, Holley T, Evers L, Posner RG, Jones T, Han H, Sausen M, Velculescu VE, Drebin J, O'Dwyer P, Jameson G, Ramanathan RK, Von Hoff DD. Clinical study of genomic drivers in pancreatic ductal adenocarcinoma. Br J Cancer. 2017 Aug 08; 117(4):572-582.

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Adams CM, Eischen CM. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer Res. 2014 Jul 15; 74(14):3923-34.

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Zhang XY, Pfeiffer HK, Mellert HS, Stanek TJ, Sussman RT, Kumari A, Yu D, Rigoutsos I, Thomas-Tikhonenko A, Seidel HE, Chodosh LA, Packham G, Baserga R, McMahon SB. Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Mol Cell Biol. 2011 Dec; 31(24):5037-45.

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DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 7; 475(7354):106-9.

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Weiss MB, Aplin AE. Paying "particle" attention to novel melanoma treatment strategies. J Invest Dermatol. 2010 Dec; 130(12):2699-701.

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Arrate MP, Vincent T, Odvody J, Kar R, Jones SN, Eischen CM. MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival. Cancer Res. 2010 Jul 15; 70(14):6083-92.

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Pomerantz MM, Beckwith CA, Regan MM, Wyman SK, Petrovics G, Chen Y, Hawksworth DJ, Schumacher FR, Mucci L, Penney KL, Stampfer MJ, Chan JA, Ardlie KG, Fritz BR, Parkin RK, Lin DW, Dyke M, Herman P, Lee S, Oh WK, Kantoff PW, Tewari M, McLeod DG, Srivastava S, Freedman ML. Evaluation of the 8q24 prostate cancer risk locus and MYC expression. Cancer Res. 2009 Jul 01; 69(13):5568-74.

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Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1; 69(5):1739-47.

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Sevilla DW, Gong JZ, Goodman BK, Buckley PJ, Rosoff P, Gockerman JP, Lagoo AS. Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation. Am J Clin Pathol. 2007 Dec; 128(6):981-91.

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