Proto-Oncogene Proteins pp60(c-src)

"Proto-Oncogene Proteins pp60(c-src)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to PP60(V-SRC) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase.

Descriptor ID	D016392
MeSH Number(s)	D08.811.913.696.620.682.725.800.630 D12.776.624.664.700.202
Concept/Terms	Proto-Oncogene Proteins pp60(c-src) Proto-Oncogene Proteins pp60(c-src) Phosphoprotein pp60(c-src) pp60 c-src c-src, pp60 pp60 c src pp60(c-src) Proto-Oncogene Protein src Protein src, Proto-Oncogene Proto Oncogene Protein src src Proto-Oncogene Product Proto-Oncogene Product, src src Proto Oncogene Product src Proto-Oncogene Protein pp60 src Proto Oncogene Protein pp60 c-src Protein pp60 Protein pp60, c-src c src Protein pp60 pp60, c-src Protein Proto-Oncogene Protein pp60(c-src)

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins pp60(c-src)".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
src-Family Kinases [D08.811.913.696.620.682.725.800]
Proto-Oncogene Proteins pp60(c-src) [D08.811.913.696.620.682.725.800.630]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins pp60(c-src)".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins pp60(c-src)".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins pp60(c-src)" by people in this website by year, and whether "Proto-Oncogene Proteins pp60(c-src)" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2004 and 2009 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2004	1	1	2
2007	1	0	1
2008	1	0	1
2009	1	1	2
2011	0	2	2
2012	0	1	1
2013	1	0	1
2017	0	1	1

Below are the most recent publications written about "Proto-Oncogene Proteins pp60(c-src)" by people in Profiles.

Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PTP4A1 promotes TGF? signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 10 20; 8(1):1060.

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Naik MU, Caplan JL, Naik UP. Junctional adhesion molecule-A suppresses platelet integrin aIIb?3 signaling by recruiting Csk to the integrin-c-Src complex. Blood. 2014 Feb 27; 123(9):1393-402.

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Dong X, Tang W, Stopenski S, Brose MS, Korch C, Meinkoth JL. RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. Endocr Relat Cancer. 2012 Aug; 19(4):575-88.

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Saxena P, Trerotola M, Wang T, Li J, Sayeed A, Vanoudenhove J, Adams DS, Fitzgerald TJ, Altieri DC, Languino LR. PSA regulates androgen receptor expression in prostate cancer cells. Prostate. 2012 May 15; 72(7):769-76.

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Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis JR, Egloff AM. Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies. Invest New Drugs. 2012 Aug; 30(4):1575-84.

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Schuh NR, Guerrero MS, Schrecengost RS, Bouton AH. BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem. 2010 Jan 22; 285(4):2309-17.

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Selvakumar P, Lakshmikuttyamma A, Das U, Pati HN, Dimmock JR, Sharma RK. NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. Mol Cancer. 2009 Aug 24; 8:65.

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Inge LJ, Rajasekaran SA, Wolle D, Barwe SP, Ryazantsev S, Ewing CM, Isaacs WB, Rajasekaran AK. alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. Mol Cancer Ther. 2008 Jun; 7(6):1386-97.

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Walker VG, Ammer A, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot H, Flynn DC. PI3K activation is required for PMA-directed activation of cSrc by AFAP-110. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C119-32.

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Gatesman A, Walker VG, Baisden JM, Weed SA, Flynn DC. Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol. 2004 Sep; 24(17):7578-97.

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