"Genes, bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Descriptor ID |
D019254
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MeSH Number(s) |
G05.360.340.024.340.375.500.791.150
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Concept/Terms |
Genes, bcl-2- Genes, bcl-2
- Genes, bcl 2
- bcl-2 Genes
- Gene, bcl-2
- bcl 2 Genes
- bcl-2 Gene
c-bcl-2 Genes- c-bcl-2 Genes
- Gene, c-bcl-2
- Genes, c-bcl-2
- c bcl 2 Genes
- c-bcl-2 Gene
- c-bcl-2 Proto-Oncogenes
- Proto-Oncogene, c-bcl-2
- Proto-Oncogenes, c-bcl-2
- c bcl 2 Proto Oncogenes
- c-bcl-2 Proto-Oncogene
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Below are MeSH descriptors whose meaning is more general than "Genes, bcl-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, bcl-2".
This graph shows the total number of publications written about "Genes, bcl-2" by people in this website by year, and whether "Genes, bcl-2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 3 | 0 | 3 |
2007 | 0 | 2 | 2 |
2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, bcl-2" by people in Profiles.
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Cohen JB, Geyer SM, Lozanski G, Zhao W, Heerema NA, Hall NC, Nagar VA, Hemminger JA, Jones JA, Porcu P, Christian BA, Baiocchi RA, Maddocks KJ, Flynn JM, Devine SM, Blum KA. Complete response to induction therapy in patients with Myc-positive and double-hit non-Hodgkin lymphoma is associated with prolonged progression-free survival. Cancer. 2014 Jun 01; 120(11):1677-85.
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Wei W, Howard PS, Kogan B, Macarak EJ. Altered extracellular matrix expression in the diverted fetal sheep bladder. J Urol. 2007 Sep; 178(3 Pt 1):1104-7.
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Tong WG, Ding XZ, Talamonti MS, Bell RH, Adrian TE. Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells. Anticancer Drugs. 2007 Jun; 18(5):535-41.
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Alabyev B, Manser T. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. J Immunol. 2002 Oct 1; 169(7):3819-24.
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Marcucci G, Byrd JC, Dai G, Klisovic MI, Kourlas PJ, Young DC, Cataland SR, Fisher DB, Lucas D, Chan KK, Porcu P, Lin ZP, Farag SF, Frankel SR, Zwiebel JA, Kraut EH, Balcerzak SP, Bloomfield CD, Grever MR, Caligiuri MA. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 2003 Jan 15; 101(2):425-32.
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Morris MJ, Tong WP, Cordon-Cardo C, Drobnjak M, Kelly WK, Slovin SF, Terry KL, Siedlecki K, Swanson P, Rafi M, DiPaola RS, Rosen N, Scher HI. Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer. Clin Cancer Res. 2002 Mar; 8(3):679-83.