NADPH Oxidases

"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.

Descriptor ID	D019255
MeSH Number(s)	D08.811.682.608.575 D12.776.331.894 D12.776.543.653
Concept/Terms	NADPH Oxidases NADPH Oxidases Oxidases, NADPH NAD(P)H oxidase NADPH Oxidase Oxidase, NADPH Nox Proteins NAD(P)H Oxidases

Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
NADH, NADPH Oxidoreductases [D08.811.682.608]
NADPH Oxidases [D08.811.682.608.575]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Flavoproteins [D12.776.331]
NADPH Oxidases [D12.776.331.894]
Membrane Proteins [D12.776.543]
NADPH Oxidases [D12.776.543.653]

Below are MeSH descriptors whose meaning is related to "NADPH Oxidases".

Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2012 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2008	1	0	1
2009	0	1	1
2011	0	1	1
2012	1	1	2
2014	1	0	1
2017	0	2	2

Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.

Nastase MV, Janicova A, Wygrecka M, Schaefer L. Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling. Antioxid Redox Signal. 2017 Oct 20; 27(12):855-873.

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Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A. Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils. . 2017 May 10; 21(5):611-618.e5.

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Kern G, Mair SM, Noppert SJ, Jennings P, Schramek H, Rudnicki M, Mueller GA, Mayer G, Koppelstaetter C. Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. PLoS One. 2014; 9(5):e96377.

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Babelova A, Avaniadi D, Jung O, Fork C, Beckmann J, Kosowski J, Weissmann N, Anilkumar N, Shah AM, Schaefer L, Schr?der K, Brandes RP. Role of Nox4 in murine models of kidney disease. Free Radic Biol Med. 2012 Aug 15; 53(4):842-53.

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Leal SM, Vareechon C, Cowden S, Cobb BA, Latgé JP, Momany M, Pearlman E. Fungal antioxidant pathways promote survival against neutrophils during infection. J Clin Invest. 2012 Jul; 122(7):2482-98.

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Lo HM, Wu MW, Pan SL, Peng CY, Wu PH, Wu WB. Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs. J Nutr Biochem. 2012 Jun; 23(6):667-78.

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Cohen JC, Killeen E, Chander A, Takemaru K, Larson JE, Treharne KJ, Mehta A. Small interfering peptide (siP) for in vivo examination of the developing lung interactonome. Dev Dyn. 2009 Feb; 238(2):386-93.

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Mantegazza AR, Savina A, Vermeulen M, P?rez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S. NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. Blood. 2008 Dec 01; 112(12):4712-22.

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Hoffmeyer MR, Jones SP, Ross CR, Sharp B, Grisham MB, Laroux FS, Stalker TJ, Scalia R, Lefer DJ. Myocardial ischemia/reperfusion injury in NADPH oxidase-deficient mice. Circ Res. 2000 Oct 27; 87(9):812-7.

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