Interleukin-18

"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Descriptor ID	D020382
MeSH Number(s)	D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
Concept/Terms	Interleukin-18 Interleukin-18 Interleukin 18 IFN-gamma-Inducing Factor IL-18 Interferon-gamma Inducing Factor Inducing Factor, Interferon-gamma Interferon gamma Inducing Factor Interferon-gamma-Inducing Factor IFN-gamma Inducing Factor IFN gamma Inducing Factor Inducing Factor, IFN-gamma IL18

Below are MeSH descriptors whose meaning is more general than "Interleukin-18".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-18 [D12.644.276.374.465.518]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-18 [D12.776.467.374.465.518]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-18 [D23.529.374.465.518]

Below are MeSH descriptors whose meaning is related to "Interleukin-18".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2003 and 2009 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2003	1	1	2
2004	0	1	1
2006	1	0	1
2007	1	0	1
2008	0	1	1
2009	1	1	2
2011	0	1	1
2016	0	2	2

Below are the most recent publications written about "Interleukin-18" by people in Profiles.

Shemesh A, Kugel A, Steiner N, Yezersky M, Tirosh D, Edri A, Teltsh O, Rosental B, Sheiner E, Rubin E, Campbell KS, Porgador A. NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint. Oncotarget. 2016 Oct 25; 7(43):70912-70923.

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Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L. An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am J Pathol. 2016 05; 186(5):1206-20.

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Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis. Clin J Am Soc Nephrol. 2011 Dec; 6(12):2740-9.

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Hall IE, Yarlagadda SG, Coca SG, Wang Z, Doshi M, Devarajan P, Han WK, Marcus RJ, Parikh CR. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol. 2010 Jan; 21(1):189-97.

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Liangos O, Tighiouart H, Perianayagam MC, Kolyada A, Han WK, Wald R, Bonventre JV, Jaber BL. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers. 2009 Sep; 14(6):423-31.

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Burt BM, Plitas G, Stableford JA, Nguyen HM, Bamboat ZM, Pillarisetty VG, DeMatteo RP. CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis. J Leukoc Biol. 2008 Oct; 84(4):1039-46.

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Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Valente AJ, Chandrasekar B. Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free Radic Biol Med. 2008 Feb 01; 44(3):284-98.

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Fain JN, Tichansky DS, Madan AK. Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes. Metabolism. 2006 Aug; 55(8):1113-21.

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Han WK, Bonventre JV. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care. 2004 Dec; 10(6):476-82.

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Zhu G, Shaffer TH, Wolfson MR. Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury. J Appl Physiol (1985). 2004 Apr; 96(4):1415-24.

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