"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Descriptor ID |
D048948
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MeSH Number(s) |
D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
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Concept/Terms |
14-3-3 Proteins- 14-3-3 Proteins
- 14 3 3 Proteins
- 14-3-3 Protein
- 14 3 3 Protein
- Brain 14-3-3 Protein
- 14-3-3 Protein, Brain
- Brain 14 3 3 Protein
- Protein 14-3-3
14-3-3 Protein, tau Isoform- 14-3-3 Protein, tau Isoform
- 14 3 3 Protein, tau Isoform
- 14-3-3tau Protein
- 14 3 3tau Protein
- Protein, 14-3-3tau
- 14-3-3 tau Protein
- 14 3 3 tau Protein
14-3-3 Protein, zeta Isoform- 14-3-3 Protein, zeta Isoform
- 14 3 3 Protein, zeta Isoform
- 14-3-3zeta Protein
- 14 3 3zeta Protein
- 14-3-3 zeta Protein
- 14 3 3 zeta Protein
14-3-3 Protein, eta Isoform- 14-3-3 Protein, eta Isoform
- 14 3 3 Protein, eta Isoform
- 14-3-3eta Protein
- 14 3 3eta Protein
- 14-3-3 eta Protein
- 14 3 3 eta Protein
- eta Protein, 14-3-3
14-3-3 Protein, epsilon Isoform- 14-3-3 Protein, epsilon Isoform
- 14 3 3 Protein, epsilon Isoform
- 14-3-3 epsilon Protein
- 14 3 3 epsilon Protein
- 14-3-3epsilon Protein
- 14 3 3epsilon Protein
14-3-3 Protein, gamma Isoform- 14-3-3 Protein, gamma Isoform
- 14 3 3 Protein, gamma Isoform
- 14-3-3gamma Protein
- 14 3 3gamma Protein
- 14-3-3 gamma Protein
- 14 3 3 gamma Protein
14-3-3 Protein, beta Isoform- 14-3-3 Protein, beta Isoform
- 14 3 3 Protein, beta Isoform
- 14-3-3beta Protein
- 14 3 3beta Protein
- 14-3-3 beta Protein
- 14 3 3 beta Protein
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Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".
Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".
This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2005 | 1 | 2 | 3 |
2006 | 0 | 1 | 1 |
2007 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.
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Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010 May; 21(5):833-43.
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Chahdi A, Sorokin A. Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol. 2008 Mar; 28(5):1679-87.
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Cunningham SC, Kamangar F, Kim MP, Hammoud S, Haque R, Iacobuzio-Donahue CA, Maitra A, Ashfaq R, Hustinx S, Heitmiller RE, Choti MA, Lillemoe KD, Cameron JL, Yeo CJ, Schulick RD, Montgomery E. Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions. Cancer Epidemiol Biomarkers Prev. 2006 Feb; 15(2):281-7.
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Jaramillo AM, Zeng H, Fei H, Zhou Y, Levitan IB. Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila. J Neurophysiol. 2006 Mar; 95(3):1957-65.
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Herron BJ, Liddell RA, Parker A, Grant S, Kinne J, Fisher JK, Siracusa LD. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005 Nov; 37(11):1210-2.
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Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M. Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms. Cancer Biol Ther. 2005 May; 4(5):596-601.
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Zhou Y, Reddy S, Murrey H, Fei H, Levitan IB. Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel. J Biol Chem. 2003 Mar 21; 278(12):10073-80.
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Cognetti D, Davis D, Sturtevant J. The Candida albicans 14-3-3 gene, BMH1, is essential for growth. Yeast. 2002 Jan 15; 19(1):55-67.