14-3-3 Proteins

"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Descriptor ID	D048948
MeSH Number(s)	D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
Concept/Terms	14-3-3 Proteins 14-3-3 Proteins 14 3 3 Proteins 14-3-3 Protein 14 3 3 Protein Brain 14-3-3 Protein 14-3-3 Protein, Brain Brain 14 3 3 Protein Protein 14-3-3 14-3-3 Protein, tau Isoform 14-3-3 Protein, tau Isoform 14 3 3 Protein, tau Isoform 14-3-3tau Protein 14 3 3tau Protein Protein, 14-3-3tau 14-3-3 tau Protein 14 3 3 tau Protein 14-3-3 Protein, zeta Isoform 14-3-3 Protein, zeta Isoform 14 3 3 Protein, zeta Isoform 14-3-3zeta Protein 14 3 3zeta Protein 14-3-3 zeta Protein 14 3 3 zeta Protein 14-3-3 Protein, eta Isoform 14-3-3 Protein, eta Isoform 14 3 3 Protein, eta Isoform 14-3-3eta Protein 14 3 3eta Protein 14-3-3 eta Protein 14 3 3 eta Protein eta Protein, 14-3-3 14-3-3 Protein, epsilon Isoform 14-3-3 Protein, epsilon Isoform 14 3 3 Protein, epsilon Isoform 14-3-3 epsilon Protein 14 3 3 epsilon Protein 14-3-3epsilon Protein 14 3 3epsilon Protein 14-3-3 Protein, gamma Isoform 14-3-3 Protein, gamma Isoform 14 3 3 Protein, gamma Isoform 14-3-3gamma Protein 14 3 3gamma Protein 14-3-3 gamma Protein 14 3 3 gamma Protein 14-3-3 Protein, beta Isoform 14-3-3 Protein, beta Isoform 14 3 3 Protein, beta Isoform 14-3-3beta Protein 14 3 3beta Protein 14-3-3 beta Protein 14 3 3 beta Protein

Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
14-3-3 Proteins [D12.776.157.057.002]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
14-3-3 Proteins [D12.776.476.024.050]

Below are MeSH descriptors whose meaning is related to "14-3-3 Proteins".

Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2005	1	2	3
2006	0	1	1
2007	1	1	2
2008	0	1	1
2010	1	0	1

Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.

Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010 May; 21(5):833-43.

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Siman R, Roberts VL, McNeil E, Dang A, Bavaria JE, Ramchandren S, McGarvey M. Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. Brain Res. 2008 Jun 05; 1213:1-11.

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Chahdi A, Sorokin A. Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol. 2008 Mar; 28(5):1679-87.

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Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, Unal O, Yun JK, Naides SJ, Kester M. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. J Biol Chem. 2007 Apr 27; 282(17):12450-7.

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Cunningham SC, Kamangar F, Kim MP, Hammoud S, Haque R, Iacobuzio-Donahue CA, Maitra A, Ashfaq R, Hustinx S, Heitmiller RE, Choti MA, Lillemoe KD, Cameron JL, Yeo CJ, Schulick RD, Montgomery E. Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions. Cancer Epidemiol Biomarkers Prev. 2006 Feb; 15(2):281-7.

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Jaramillo AM, Zeng H, Fei H, Zhou Y, Levitan IB. Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila. J Neurophysiol. 2006 Mar; 95(3):1957-65.

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Herron BJ, Liddell RA, Parker A, Grant S, Kinne J, Fisher JK, Siracusa LD. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005 Nov; 37(11):1210-2.

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Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M. Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms. Cancer Biol Ther. 2005 May; 4(5):596-601.

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Zhou Y, Reddy S, Murrey H, Fei H, Levitan IB. Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel. J Biol Chem. 2003 Mar 21; 278(12):10073-80.

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Cognetti D, Davis D, Sturtevant J. The Candida albicans 14-3-3 gene, BMH1, is essential for growth. Yeast. 2002 Jan 15; 19(1):55-67.

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