Transcription Factor AP-2

"Transcription Factor AP-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Descriptor ID	D050656
MeSH Number(s)	D12.776.260.760 D12.776.930.907
Concept/Terms	Transcription Factor AP-2 Transcription Factor AP-2 AP-2, Transcription Factor Transcription Factor AP 2 Transcription Factor AP2 Enhancer-Binding Protein AP-2 AP-2, Enhancer-Binding Protein Enhancer Binding Protein AP 2 Activator Protein AP-2 AP-2, Activator Protein Activator Protein AP 2 AP-2 Enhancer Binding Protein AP 2 Enhancer Binding Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP 2 epsilon Protein Transcription Factor AP-2epsilon AP-2epsilon, Transcription Factor Transcription Factor AP 2epsilon AP-2 epsilon Protein Transcription Factor AP-2 beta Protein Transcription Factor AP-2 beta Protein Transcription Factor AP 2 beta Protein TFAP2B Protein Transcription Factor AP-2beta AP-2beta, Transcription Factor Transcription Factor AP 2beta AP-2 beta Protein AP 2 beta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP 2 delta Protein Transcription Factor Ap-2delta Ap-2delta, Transcription Factor Transcription Factor Ap 2delta AP-2delta Protein AP 2delta Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP 2 gamma Protein Transcription Factor AP-2gamma AP-2gamma, Transcription Factor Transcription Factor AP 2gamma AP-2 gamma Protein AP 2 gamma Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP 2 alpha Protein AP-2 alpha Protein AP 2 alpha Protein TFAP2alpha Protein Transcription Factor AP-2alpha AP-2alpha, Transcription Factor Transcription Factor AP 2alpha

Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Transcription Factor AP-2 [D12.776.260.760]
Transcription Factors [D12.776.930]
Transcription Factor AP-2 [D12.776.930.907]

Below are MeSH descriptors whose meaning is related to "Transcription Factor AP-2".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Factor AP-2" by people in this website by year, and whether "Transcription Factor AP-2" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2007 and 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	1	1
1999	0	1	1
2007	1	1	2
2008	1	0	1
2009	1	1	2
2011	1	0	1

Below are the most recent publications written about "Transcription Factor AP-2" by people in Profiles.

Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Ch?nier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32.

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Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S. Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009 Aug 15; 69(16):6445-53.

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Igoucheva O, Alexeev V. MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem Biophys Res Commun. 2009 Feb 13; 379(3):790-4.

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Milunsky JM, Maher TA, Zhao G, Roberts AE, Stalker HJ, Zori RT, Burch MN, Clemens M, Mulliken JB, Smith R, Lin AE. TFAP2A mutations result in branchio-oculo-facial syndrome. Am J Hum Genet. 2008 May; 82(5):1171-7.

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Iczkowski KA, Butler SL, Shanks JH, Hossain D, Schall A, Meiers I, Zhou M, Torkko KC, Kim SJ, MacLennan GT. Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. Hum Pathol. 2008 Feb; 39(2):275-81.

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Han S, Ritzenthaler JD, Wingerd B, Rivera HN, Roman J. Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2. J Biol Chem. 2007 Mar 16; 282(11):7961-72.

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Pena P, Reutens AT, Albanese C, D'Amico M, Watanabe G, Donner A, Shu IW, Williams T, Pestell RG. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol. 1999 Aug; 13(8):1402-16.

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Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL. Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2. J Biol Chem. 1997 Jun 13; 272(24):15405-12.

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Warren G, Gordon M, Siracusa LD, Buchberg AM, Williams T. Physical and genetic localization of the gene encoding the AP-2 transcription factor to mouse chromosome 13. Genomics. 1996 Jan 15; 31(2):234-7.

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