Crk-Associated Substrate Protein
"Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
| Descriptor ID |
D050719
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| MeSH Number(s) |
D12.644.360.024.282 D12.776.157.057.016 D12.776.476.024.316 D12.776.744.425
|
| Concept/Terms |
Crk-Associated Substrate Protein- Crk-Associated Substrate Protein
- Crk Associated Substrate Protein
- Substrate Protein, Crk-Associated
- p130 Cas Protein
- Cas Protein, p130
- BCAR1 Protein
- p130 Crk-Associated Substrate
- Crk-Associated Substrate, p130
- Substrate, p130 Crk-Associated
- p130 Crk Associated Substrate
- p130Cas Protein
- Breast Cancer Anti-Estrogen Resistance 1 Protein
- Breast Cancer Anti Estrogen Resistance 1 Protein
- Crk-Associated Substrate
- Crk Associated Substrate
- CKRAS Protein
|
Below are MeSH descriptors whose meaning is more general than "Crk-Associated Substrate Protein".
Below are MeSH descriptors whose meaning is more specific than "Crk-Associated Substrate Protein".
This graph shows the total number of publications written about "Crk-Associated Substrate Protein" by people in this website by year, and whether "Crk-Associated Substrate Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Crk-Associated Substrate Protein" by people in Profiles.
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Cito L, Indovina P, Forte IM, Pentimalli F, Di Marzo D, Somma P, Barone D, Penon A, Penon D, Ceccherini E, Micheli P, Saragoni L, Di Domenico M, Feola A, Roviello F, Mattioli E, Giordano GG, Giordano A. pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer. J Cell Physiol. 2015 Apr; 230(4):802-5.
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Schuh NR, Guerrero MS, Schrecengost RS, Bouton AH. BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem. 2010 Jan 22; 285(4):2309-17.
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Ta HQ, Thomas KS, Schrecengost RS, Bouton AH. A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer Res. 2008 Nov 1; 68(21):8796-804.
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Sabri A, Rafiq K, Seqqat R, Kolpakov MA, Dillon R, Dell'italia LJ. Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog. Circ Res. 2008 May 9; 102(9):1127-36.
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Schrecengost RS, Riggins RB, Thomas KS, Guerrero MS, Bouton AH. Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res. 2007 Jul 1; 67(13):6174-82.
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Bovicelli A, D'Andrilli G, Giordano A. Multidisciplinary International Conference on Gynecologic Cancer, Bologna, Italy, June 8-12, 2005. J Cell Physiol. 2006 Jul; 208(1):1-5.