Class I Phosphatidylinositol 3-Kinases

"Class I Phosphatidylinositol 3-Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A phosphatidylinositol 3-kinase subclass that includes enzymes with a specificity for 1-phosphatidylinositol, 1-phosphatidylinositol 4-phosphate, and 1-phosphatidylinositol 4,5-bisphosphate. Members of this enzyme subclass are activated by cell surface receptors and occur as heterodimers of enzymatic and regulatory subunits.

Descriptor ID	D058534
MeSH Number(s)	D08.811.913.696.620.500.100.100 D08.811.913.696.620.500.200.100 D12.776.476.162
Concept/Terms	Class I Phosphatidylinositol 3-Kinases Class I Phosphatidylinositol 3-Kinases Class I Phosphatidylinositol 3 Kinases Class I Phosphatidylinositol 3-Kinase Class I Phosphatidylinositol 3 Kinase Phosphatidylinositol 3-Kinase, Class I Phosphatidylinositol 3 Kinase, Class I

Below are MeSH descriptors whose meaning is more general than "Class I Phosphatidylinositol 3-Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100]
Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.100.100]
Phosphatidylinositol-4-Phosphate 3-Kinase [D08.811.913.696.620.500.200]
Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.200.100]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Class I Phosphatidylinositol 3-Kinases [D12.776.476.162]

Below are MeSH descriptors whose meaning is related to "Class I Phosphatidylinositol 3-Kinases".

Below are MeSH descriptors whose meaning is more specific than "Class I Phosphatidylinositol 3-Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Class I Phosphatidylinositol 3-Kinases" by people in this website by year, and whether "Class I Phosphatidylinositol 3-Kinases" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2014 and 2016 and 2017 and 2018 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	0	1	1
2016	0	1	1
2017	0	1	1
2018	1	0	1
2022	0	1	1

Below are the most recent publications written about "Class I Phosphatidylinositol 3-Kinases" by people in Profiles.

Waks AG, Kim D, Jain E, Snow C, Kirkner GJ, Rosenberg SM, Oh C, Poorvu PD, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Brachtel EF, Warner E, Collins LC, Partridge AH, Wagle N. Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer. Clin Cancer Res. 2022 Jun 01; 28(11):2339-2348.

View in: PubMed
Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018 05 08; 9(1):1816.

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Chae YK, Davis AA, Jain S, Santa-Maria C, Flaum L, Beaubier N, Platanias LC, Gradishar W, Giles FJ, Cristofanilli M. Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer. Mol Cancer Ther. 2017 Jul; 16(7):1412-1420.

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Vahidnezhad H, Youssefian L, Baghdadi T, Sotoudeh S, Tavassoli A, Zeinali S, Afsharaalam S, Uitto J. Phenotypic heterogeneity in PIK3CA-related overgrowth spectrum. Br J Dermatol. 2016 Oct; 175(4):810-4.

View in: PubMed
Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20.

View in: PubMed

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