Wnt Signaling Pathway

"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.

Descriptor ID	D060449
MeSH Number(s)	G02.111.820.925 G04.835.925
Concept/Terms	Wnt Signaling Pathway Wnt Signaling Pathway Pathway, Wnt Signaling Pathways, Wnt Signaling Signaling Pathway, Wnt Signaling Pathways, Wnt Wnt Signaling Pathways Wnt Pathway Pathway, Wnt Pathways, Wnt Wnt Pathways Wnt beta-Catenin Signaling Pathway Wnt beta-Catenin Signaling Pathway Wnt beta Catenin Signaling Pathway Wnt Pathway, Canonical Canonical Wnt Pathway Canonical Wnt Pathways Pathway, Canonical Wnt Pathways, Canonical Wnt Wnt Pathways, Canonical

Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Wnt Signaling Pathway [G02.111.820.925]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Wnt Signaling Pathway [G04.835.925]

Below are MeSH descriptors whose meaning is related to "Wnt Signaling Pathway".

Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in this website by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.

Bar chart showing 47 publications over 15 distinct years, with a maximum of 8 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	1	2
2012	3	1	4
2013	1	0	1
2014	2	1	3
2015	6	2	8
2016	0	3	3
2017	1	2	3
2018	2	3	5
2019	0	3	3
2020	3	3	6
2021	1	3	4
2022	1	1	2
2023	0	1	1
2024	1	0	1
2025	1	0	1

Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles.

Hartmann HA, Loberg MA, Xu GJ, Schwarzkopf AC, Chen SC, Phifer CJ, Caroland K, Chen HC, Diaz D, Tigue ML, Hesterberg AB, Gallant JN, Shaddy SM, Sheng Q, Netterville JL, Rohde SL, Sol?rzano CC, Bischoff LA, Baregamian N, Hurley PJ, Murphy BA, Choe JH, Huang EC, Ye F, Lee E, Weiss VL. Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer. Endocrinology. 2025 Feb 05; 166(3).

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Chehade H, Gogoi R, Adzibolosu NK, Galoforo S, Fehmi RA, Kheil M, Fox A, Kim S, Rattan R, Hou Z, Morris RT, Matherly LH, Mor G, Alvero AB. BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer. Cancer Res Commun. 2024 08 01; 4(8):2075-2088.

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Ventura E, Belfiore A, Iozzo RV, Giordano A, Morrione A. Progranulin and EGFR modulate receptor-like tyrosine kinase sorting and stability in mesothelioma cells. Am J Physiol Cell Physiol. 2023 08 01; 325(2):C391-C405.

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Kayumi S, P?rez-Jurado LA, Palomares M, Rangu S, Sheppard SE, Chung WK, Kruer MC, Kharbanda M, Amor DJ, McGillivray G, Cohen JS, Garc?a-Mi?a?r S, van Eyk CL, Harper K, Jolly LA, Webber DL, Barnett CP, Santos-Simarro F, Pacio-M?guez M, Pozo AD, Bakhtiari S, Deardorff M, Dubbs HA, Izumi K, Grand K, Gray C, Mark PR, Bhoj EJ, Li D, Ortiz-Gonzalez XR, Keena B, Zackai EH, Goldberg EM, Perez de Nanclares G, Pereda A, Llano-Rivas I, Arroyo I, Fern?ndez-Cuesta M?, Thauvin-Robinet C, Faivre L, Garde A, Mazel B, Bruel AL, Tress ML, Brilstra E, Fine AS, Crompton KE, Stegmann APA, Sinnema M, Stevens SCJ, Nicolai J, Lesca G, Lion-Fran?ois L, Haye D, Chatron N, Piton A, Nizon M, Cogne B, Srivastava S, Bassetti J, Muss C, Gripp KW, Procopio RA, Millan F, Morrow MM, Assaf M, Moreno-De-Luca A, Joss S, Hamilton MJ, Bertoli M, Foulds N, McKee S, MacLennan AH, Gecz J, Corbett MA. Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants. Genet Med. 2022 11; 24(11):2351-2366.

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Armstrong A, Mandala A, Malhotra M, Gnana-Prakasam JP. Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases. Oxid Med Cell Longev. 2022; 2022:7163326.

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Bell IJ, Horn MS, Van Raay TJ. Bridging the gap between non-canonical and canonical Wnt signaling through Vangl2. Semin Cell Dev Biol. 2022 05; 125:37-44.

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Mandala A, Chen WJ, Armstrong A, Malhotra MR, Chavalmane S, McCommis KS, Chen A, Carpenter D, Biswas P, Gnana-Prakasam JP. PPARa agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and ?-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(4):G262-G269.

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Del Bosque-Plata L, Mart?nez-Mart?nez E, Espinoza-Camacho M?, Gragnoli C. The Role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021 06; 70(6):1220-1228.

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Soldi R, Halder TG, Sampson S, Vankayalapati H, Weston A, Thode T, Bhalla KN, Ng S, Rodriguez Del Villar R, Drenner K, Kaadige MR, Horrigan SK, Batra SK, Salgia R, Sharma S. The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ?-Like 1-?-Catenin Protein Complex. J Pharmacol Exp Ther. 2021 Aug; 378(2):77-86.

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Zhang T, Ahn K, Emerick B, Modarai SR, Opdenaker LM, Palazzo J, Schleiniger G, Fields JZ, Boman BM. APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development. PLoS One. 2020; 15(10):e0239601.

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