"DNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
| Descriptor ID |
D004256
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| MeSH Number(s) |
D08.811.913.696.445.308.300.225
|
| Concept/Terms |
DNA Polymerase I- DNA Polymerase I
- Polymerase I, DNA
- Klenow Fragment
- DNA-Dependent DNA Polymerase I
- DNA Dependent DNA Polymerase I
- DNA Pol I
- DNA Polymerase alpha
- Polymerase alpha, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Polymerase I".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase I".
This graph shows the total number of publications written about "DNA Polymerase I" by people in this website by year, and whether "DNA Polymerase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase I" by people in Profiles.
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Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE. Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. J Mol Biol. 2020 12 04; 432(24):166698.
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Mason AC, Roy R, Simmons DT, Wold MS. Functions of alternative replication protein A in initiation and elongation. Biochemistry. 2010 Jul 20; 49(28):5919-28.
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Quarless SA. Coupled endo-exodeoxyribonuclease activity from HeLa cell nuclei can function in an excision repair mode in vitro. Biochem Biophys Res Commun. 1985 Jan 31; 126(2):812-7.
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Quarless SA. Coupled endo-exodeoxyribonuclease activity from HeLa cell nuclei interacts with specific regions of the SV40 mini chromosome. Biochem Biophys Res Commun. 1985 Jan 31; 126(2):805-11.