Receptors, Corticotropin-Releasing Hormone

"Receptors, Corticotropin-Releasing Hormone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.

Descriptor ID	D018019
MeSH Number(s)	D12.776.543.750.695.180 D12.776.543.750.720.600.290 D12.776.543.750.750.555.290 D12.776.543.750.750.700.150
Concept/Terms	Receptors, Corticotropin-Releasing Hormone Receptors, Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone Receptors Hormone Receptors, Corticotropin-Releasing Receptors, Corticotropin Releasing Hormone Corticotropin Releasing-Hormone Receptors Corticotropin Releasing Hormone Receptors Receptors, Corticotropin Releasing-Hormone Releasing-Hormone Receptors, Corticotropin CRF Receptors Corticotropin Releasing-Factor Receptors Corticotropin Releasing Factor Receptors Receptors, Corticotropin Releasing-Factor Releasing-Factor Receptors, Corticotropin Receptors, CRF CRH Receptor Receptor, CRH CRH Receptors Receptors, CRH Corticotropin Releasing-Hormone Receptor Corticotropin Releasing Hormone Receptor Receptor, Corticotropin Releasing-Hormone Releasing-Hormone Receptor, Corticotropin CRF Receptor Receptor, CRF

Below are MeSH descriptors whose meaning is more general than "Receptors, Corticotropin-Releasing Hormone".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.695.180]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Neuropeptide [D12.776.543.750.720.600]
Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.720.600.290]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Neuropeptide [D12.776.543.750.750.555]
Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.750.555.290]
Receptors, Pituitary Hormone-Regulating Hormone [D12.776.543.750.750.700]
Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.750.700.150]

Below are MeSH descriptors whose meaning is related to "Receptors, Corticotropin-Releasing Hormone".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Corticotropin-Releasing Hormone".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Corticotropin-Releasing Hormone" by people in this website by year, and whether "Receptors, Corticotropin-Releasing Hormone" was a major or minor topic of these publications.

Bar chart showing 21 publications over 13 distinct years, with a maximum of 3 publications in 2012 and 2013 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2006	2	0	2
2007	1	0	1
2009	1	0	1
2011	0	1	1
2012	1	2	3
2013	1	2	3
2015	0	1	1
2016	1	0	1
2018	1	0	1
2019	0	3	3
2022	1	0	1
2023	1	1	2

Below are the most recent publications written about "Receptors, Corticotropin-Releasing Hormone" by people in Profiles.

Del Bosque-Plata L, Amin M, Gonz?lez-Ram?rez R, Wu R, Postolache TT, Vergare M, Gordon D, Gragnoli C. LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity. Eur Arch Psychiatry Clin Neurosci. 2025 Jun; 275(4):1025-1035.

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Amin M, Horst N, Wu R, Gragnoli C. Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. J Ovarian Res. 2023 Aug 05; 16(1):155.

View in: PubMed
Amin M, Ott J, Gordon D, Wu R, Postolache TT, Vergare M, Gragnoli C. Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression. Int J Mol Sci. 2022 Aug 29; 23(17).

View in: PubMed
Ross JA, Alexis R, Reyes BAS, Risbrough V, Van Bockstaele EJ. Localization of amyloid beta peptides to locus coeruleus and medial prefrontal cortex in corticotropin releasing factor overexpressing male and female mice. Brain Struct Funct. 2019 Sep; 224(7):2385-2405.

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Serova LI, Nwokafor C, Van Bockstaele EJ, Reyes BAS, Lin X, Sabban EL. Single prolonged stress PTSD model triggers progressive severity of anxiety, altered gene expression in locus coeruleus and hypothalamus and effected sensitivity to NPY. Eur Neuropsychopharmacol. 2019 04; 29(4):482-492.

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Reyes BAS, Zhang XY, Dufourt EC, Bhatnagar S, Valentino RJ, Van Bockstaele EJ. Neurochemically distinct circuitry regulates locus coeruleus activity during female social stress depending on coping style. Brain Struct Funct. 2019 May; 224(4):1429-1446.

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Enman NM, Reyes BAS, Shi Y, Valentino RJ, Van Bockstaele EJ. Sex differences in morphine-induced trafficking of mu-opioid and corticotropin-releasing factor receptors in locus coeruleus neurons. Brain Res. 2019 03 01; 1706:75-85.

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Shenoda BB, Alexander GM, Ajit SK. Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome. J Transl Med. 2016 Mar 03; 14:64.

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Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M. The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology. 2015 Mar 13; 40(5):1053-63.

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Valentino RJ, Van Bockstaele E, Bangasser D. Sex-specific cell signaling: the corticotropin-releasing factor receptor model. Trends Pharmacol Sci. 2013 Aug; 34(8):437-44.

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