Frizzled Receptors

"Frizzled Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of seven-pass transmembrane cell-surface proteins that combines with LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 or LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 to form receptors for WNT PROTEINS. Frizzled receptors often couple with HETEROTRIMERIC G PROTEINS and regulate the WNT SIGNALING PATHWAY.

Descriptor ID	D051157
MeSH Number(s)	D12.776.543.750.695.017 D12.776.543.750.850.500
Concept/Terms	Frizzled Receptors Frizzled Receptors Frizzled Receptor Receptor, Frizzled Receptors, Frizzled Frizzled Proteins

Below are MeSH descriptors whose meaning is more general than "Frizzled Receptors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Frizzled Receptors [D12.776.543.750.695.017]
Receptors, Wnt [D12.776.543.750.850]
Frizzled Receptors [D12.776.543.750.850.500]

Below are MeSH descriptors whose meaning is related to "Frizzled Receptors".

Below are MeSH descriptors whose meaning is more specific than "Frizzled Receptors".

Frizzled Receptors
Smoothened Receptor

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Frizzled Receptors" by people in this website by year, and whether "Frizzled Receptors" was a major or minor topic of these publications.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 3 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2009	1	0	1
2010	1	0	1
2013	1	1	2
2015	0	2	2
2020	1	1	2
2022	0	3	3
2023	0	1	1

Below are the most recent publications written about "Frizzled Receptors" by people in Profiles.

Wakabayashi T, Patel SN, Starr MR, Yonekawa Y. 18p Deletion Syndrome With Concurrent Frizzled-4 Mutation: Surgical Management of Bilateral Stage 5 Traction Retinal Detachment. Ophthalmic Surg Lasers Imaging Retina. 2023 05; 54(5):284-290.

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Jimenez HJ, Procopio RA, Thuma TBT, Marra MH, Izquierdo N, Klufas MA, Nagiel A, Pennesi ME, Pulido JS. Signal Peptide Variants in Inherited Retinal Diseases: A Multi-Institutional Case Series. Int J Mol Sci. 2022 Nov 01; 23(21).

View in: PubMed
van der Ende SR, Meyers BS, Capasso JE, Sasongko M, Yonekawa Y, Pihlblad M, Huey J, Bedoukian EC, Krantz ID, Ngo MH, McMaster CR, Levin AV, Robitaille JM. Severe Familial Exudative Vitreoretinopathy, Congenital Hearing Loss, and Developmental Delay in a Child With Biallelic Variants in FZD4. JAMA Ophthalmol. 2022 09 01; 140(9):889-893.

View in: PubMed
Restrepo LJ, DePew AT, Moese ER, Tymanskyj SR, Parisi MJ, Aimino MA, Duhart JC, Fei H, Mosca TJ. ?-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor. Dev Cell. 2022 07 11; 57(13):1643-1660.e7.

View in: PubMed
Yu J, Yusoff PAM, Woutersen DTJ, Goh P, Harmston N, Smits R, Epstein DM, Virshup DM, Madan B. The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition. Cancer Res. 2020 12 15; 80(24):5619-5632.

View in: PubMed
Kushwaha P, Kim S, Foxa GE, Michalski MN, Williams BO, Tomlinson RE, Riddle RC. Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8. J Cell Physiol. 2020 10; 235(10):6673-6683.

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Mammo D, Yonekawa Y, Thomas BJ, Shah AR, Abbey AM, Trese MT, Drenser KA, Capone A. Association of autosomal dominant familial exudative vitreoretinopathy and spinal muscular atrophy. Eur J Ophthalmol. 2015 Oct 21; 25(6):e116-8.

View in: PubMed
Yonekawa Y, Thomas BJ, Drenser KA, Trese MT, Capone A. Familial Exudative Vitreoretinopathy: Spectral-Domain Optical Coherence Tomography of?the?Vitreoretinal Interface, Retina, and Choroid. Ophthalmology. 2015 Nov; 122(11):2270-7.

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Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA. Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell. 2013 Aug 26; 26(4):346-57.

View in: PubMed
Wilson NJ, Hansen CD, Azkur D, Kocabas CN, Metin A, Coskun Z, Schwartz ME, Hull PR, McLean WH, Smith FJ. Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita. J Dermatol Sci. 2013 Apr; 70(1):58-60.

View in: PubMed

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