A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

Descriptor ID	D005784
MeSH Number(s)	G05.308.250 G05.365.590.310 G05.558.315
Concept/Terms	Gene Amplification Gene Amplification Amplification, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Amplification".

Below are MeSH descriptors whose meaning is related to "Gene Amplification".

Below are MeSH descriptors whose meaning is more specific than "Gene Amplification".