Ku Autoantigen

"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.

Descriptor ID	D000072200
MeSH Number(s)	D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
Concept/Terms	Ku Autoantigen Ku Autoantigen Autoantigen, Ku Ku Heterodimer Heterodimer, Ku Ku Protein Ku Antigen Antigen, Ku G22P1 Antigen Antigen, G22P1 Ku80 Antigen Ku80 Antigen Antigen, Ku80 Ku Autoantigen, 80 kDa XRCC5 Protein X-ray Repair Cross-Complementing Protein 5 X ray Repair Cross Complementing Protein 5 Ku70 Antigen Ku70 Antigen Antigen, Ku70 Ku Autoantigen, 70 kDa XRCC6 Protein X-ray Repair Cross-Complementing Protein 6 X ray Repair Cross Complementing Protein 6

Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
DNA Helicases [D08.811.277.040.025.159]
Ku Autoantigen [D08.811.277.040.025.159.155]
Isomerases [D08.811.399]
DNA Helicases [D08.811.399.340]
Ku Autoantigen [D08.811.399.340.155]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Ku Autoantigen [D12.776.157.687.493]
DNA-Binding Proteins [D12.776.260]
Ku Autoantigen [D12.776.260.525]
Nuclear Proteins [D12.776.660]
Antigens, Nuclear [D12.776.660.625]
Ku Autoantigen [D12.776.660.625.625]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Ku Autoantigen [D12.776.660.720.493]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Nuclear [D23.050.290]
Ku Autoantigen [D23.050.290.625]

Below are MeSH descriptors whose meaning is related to "Ku Autoantigen".

Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 3 publications in 2002 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2002	0	3	3
2003	0	1	1
2004	0	1	1
2006	0	2	2
2007	0	3	3
2010	0	1	1
2012	0	2	2
2013	0	1	1
2014	0	1	1
2016	1	1	2
2021	0	1	1

Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.

Iliakis GE. New Players in the Regulation of DNA-PK Activity: Survivin Joins the Crowd. Cancer Res. 2021 05 01; 81(9):2270-2271.

View in: PubMed
van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell. 2016 10 06; 64(1):189-198.

View in: PubMed
Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA. Essential Roles for Polymerase ?-Mediated End Joining in the Repair of Chromosome Breaks. Mol Cell. 2016 08 18; 63(4):662-673.

View in: PubMed
Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA. Requirements for 5'dRP/AP lyase activity in Ku. Nucleic Acids Res. 2014; 42(17):11136-43.

View in: PubMed
Taleei R, Nikjoo H. The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model. Radiat Res. 2013 May; 179(5):530-9.

View in: PubMed
Li J, Ward KM, Zhang D, Dayanandam E, Denittis AS, Prendergast GC, Ayene IS. A bioactive probe of the oxidative pentose phosphate cycle: novel strategy to reverse radioresistance in glucose deprived human colon cancer cells. Toxicol In Vitro. 2013 Feb; 27(1):367-77.

View in: PubMed
Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA. Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends. J Biol Chem. 2012 Apr 20; 287(17):13686-93.

View in: PubMed
Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA. Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 2010 Apr 22; 464(7292):1214-7.

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Wu W, Wang M, Wu W, Singh SK, Mussfeldt T, Iliakis G. Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2. DNA Repair (Amst). 2008 Feb 01; 7(2):329-38.

View in: PubMed
Ramalingam A, Farmer GE, Stamato TD, Prendergast GC. Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle. 2007 Aug 01; 6(15):1914-8.

View in: PubMed

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